@article {822, title = {Phytochemical Compounds Of Cichorium intybus by Exploring its Antioxidant and Antidiabetic Activities}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {February 2019}, pages = {248-257}, type = {Research Article}, chapter = {248}, abstract = {

Introduction: The current study aims to evaluate the therapeutic effect of Cichorium intybus n-hexane extract on diabetes mellitus and its antioxidant effect in vivo in alloxinated animals. Diabetic neuropathy improvement was also tested as well as insulin levels and histology of the pancreas were performed. Methods: The chromatographic standardization of C. intybus extract was performed using isocratic HPLC, which indicated the presence of numerous phyto-constituents. The hexane extract was studied for its effect on blood glucose levels and painful diabetic neuropathy (DN) in diabetic mice. Hyperalgesia and mechanical-allodynia were evaluated using thermal stimuli, pain response to radiant energy experiments and a mechanical sensitivity test respectively. Subsequently, after eight weeks of being alloxinated, BGL, body weight, antioxidant activity, insulin levels and glycated hemoglobin were recorded to evaluate antidiabetic potential and the DN. Results: The administration of Cichorium intybus extract (50, 75 and 100 mg/kg) and a combination of Cichorium intybus extract and Camellia sinensis (50 + 200 mg/kg, respectively) have revealed an acute hypoglycemic effect ranging from 14.15\% and 42.4\%. The sub-chronic anti-diabetic effect ranged from 23.41\% and 44.8\%. They diminished hyperalgesia and tangible allodynia significantly (p\<0.05), (n=7 per group). The powerful neuroprotective properties might serve as potential lead-compounds for further analysis. Conclusion: The histological study and the potent antioxidant effect showed that they could assist in the management of diabetes mellitus and DN by amelioration of insulin levels and regeneration of pancreatic beta cells.

}, keywords = {Antidiabetic effects, Antioxidant, Cichorium Intybus, Phytochemical analysis, Serum insulin}, doi = {10.5530/pj.2019.11.39}, author = {Dina Kanj and Karim Raafat and Abdalla El-Lakany and Safaa Baydoun and Maha Aboul-Ela} } @article {429, title = {Chemo-profiling, Antioxidant Potential and Ionomic Analysis of Cichorium intybus L.}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {917-928}, type = {Original Article}, chapter = {917}, abstract = {

Background: Cichorium intybus commonly called as chicory or coffee weed was traditionally used for the treatment of various ailments associated with liver, kidney and heart. The aim of the present study was phytochemical screening, in-vitro evaluation of antioxidant potential, element analysis of wild and cultivated chicory and GC-MS analysis of methanolic leaf extract of wild chicory grown in Kashmir Himalaya. Method: To achieve this goal, the qualitative and quantitative analysis was done to determine the antioxidant potential. Element analysis was done using AAS and metabolite fingerprinting was done using GC-MS to ascertain the presence of active phytoconstituents in chicory leaves. Results: The qualitative screening of leaf extracts from wild and cultivated chicory indicates the presence of important bioactive constituents. The leaf extract of wild chicory constituted the higher amount of total phenol and flavonoid contents and also showed strong radical scavenging activities of DPPH, SOD and hydrogen peroxide radical as indicated by lower values of IC50 compared to cultivated chicory. Furthermore, both extracts of wild chicory showed the highest total antioxidant potential for the reduction of Fe3+ to Fe2+ when compared with cultivated chicory. The results from the elemental analysis shows that leaf extract of wild chicory exhibits higher concentration of elements as compared to cultivated one, thus can be used as a potential bio-fortified crop. The GC-MS analysis determines the presence of 78 different compounds in the methanolic leaf extract of wild chicory. The major phytochemical constituents were phytol (7.96\%) and stigmat-5-en-3-ol (6.45\%). Conclusion: The findings of the present study suggested the therapeutic potential of chicory leaves; particularly wild chicory proves to be a potent source of natural antioxidant against free radical associated damages. Metabolite profiling study revealed important metabolites having potent pharmacological actions.

}, keywords = {Aas, Antioxidant Activities, Cichorium Intybus, GC-MS., Phytochemical analysis}, doi = {10.5530/pj.2017.6.144}, url = {http://fulltxt.org/article/197}, author = {Bisma Malik and Tanveer Bilal Pirzadah and Inayatullah Tahir and Reiaz Ul Rehman} }