@article {2454, title = {Citrus Extract-Mediated Zinc Oxide Nanoparticles and Their Capacity to Attenuate Free Radicals and Inflammation}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {December 2024}, pages = {1222-1233}, type = {Research Article}, chapter = {1222}, abstract = {

Introduction: The exploitation of plant materials for the green synthesis of nanoparticles (NPs) for biological applications, is considered an eco-friendly technology because it does not involve the use of toxic chemicals. Objective: The study was carried out to synthesize citrus extract-mediated ZnO NPs and evaluate their free radical scavenging and anti-inflammatory capacity. Materials and Methods: ZnO NPs were green synthesized, using the peel and leaf aqueous extracts of three citrus plants: Nova mandarin, Satsuma mandarin and Eureka lemon. The citrus extract based ZnO NPs were characterized by UV-Vis and FTIR spectroscopy, microscopy (SEM and TEM), EDX and XRD analyses. They were screened against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO) free radicals. Finally, their inhibitory effects against egg albumin denaturation (EAD) were determined spectrophotometrically. Results: The six afforded biogenic NPs consistently exhibited FTIR vibrational band around 500 cm-1, which is characteristics of a metal oxide (Zn-O) band. They also showed UV-Vis absorption peaks at 387 and 415 nm, suggesting the formation of ZnO NPs. Nova mandarin peel (NMP) ZnO NPs exhibited the best DPPH and NO radical scavenging activities, with 50\% inhibitory concentration (IC50) of 7.61{\textpm}0.69 and 19.93{\textpm}0.40 μg/mL, respectively. It also gave the best inhibition against EAD, with an IC50 of 14.80{\textpm}1.29 μg/mL. Morphological assessment of NMP extract-based ZnO NPs revealed rod-shaped particles at 35-50 nm range. Conclusion: It has been shown through this study that citrus extract based ZnO NPs, especially those prepared with NMP, may have the capacity to attenuate free radical release and inflammation in biological systems.

}, keywords = {Anti-inflammatory capacity, Citrus plants, Free Radical Scavenging Activity, Nova mandarin, Zinc oxide nanoparticle green synthesis}, doi = {10.5530/pj.2024.16s.236}, author = {Tabisa Diniso and Ayodeji O. Oriola and Gugulethu M. Miya and Simon K. Kuria and Yiseyon S. Hosu and Opeoluwa O. Oyedeji and Mike O. Ojemaye and Ludwe Majiza and Jerry O. Adeyemi and Adebola O. Oyedeji} } @article {430, title = {Total Phenolic Contents and Free Radical Scavenging Activity of Guaiacum officinale L. Extracts}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {929-931}, type = {Original Article}, chapter = {929}, abstract = {

Backgound: Guaiacum officinale L. is an alien species to Thailand. It is used as anti-arthritis and anti-rheumatoid agents in Indian folklore medicine. Objective: The present study was aimed to investigate total phenolic contents and free radical scavenging activity of the extracts from Guaiacum officinale L. (Zygophyllaceae). Methods: The plant parts including bark, twig and leaf were extracted using different solvents (ethyl acetate, water and ethanol). Total phenolic contents were determined by Folin-Ciocalteu Colorimetry method while free radical scavenging activity of the extracts was investigated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. Results: The results show that the highest total phenolic content is found in the ethyl acetate twig extracts (20.3\±0.0031 \μg GAE/1 \μg extracts). The ethanolic twig extracts had the highest free radical scavenging activity with IC50 of 0.45\±0.0188 mg/ml. Conclusion: The extracts from Guaiacum officinale L. exhibit good anti-oxidant activity and may be suitable for development as drugs and supplementary food.

}, keywords = {Ethanolic twig extracts, Ethyl acetate twig extracts., Free Radical Scavenging Activity, Guaiacum Officinale L, Total Phenolic Contents}, doi = {10.5530/pj.2017.6.145}, url = {http://fulltxt.org/article/198}, author = {Suthira Maneechai and Vachiraporn Pikulthong} } @article {1487, title = {Chemical Constituents of Dendrobium williamsonii}, journal = {Pharmacognosy journal}, volume = {6}, year = {2014}, month = {8th April 2014}, pages = {36-41}, type = {Original Article}, abstract = {

Objective: Isolation of compounds from Dendrobium williamsonii and evaluation of each isolates for its free radical scavenging, antiherpetic and cytotoxic activities. Results: Six phenolic compounds were isolated including tetratriacontanyltrans- p-coumarate (1), trans-docosanoylferulate (2), 3,3\′-dihydroxy-4,5-dimethoxybibenzyl (3), moscatilin (4), apigenin (5) and vanillic acid (6). Among these isolates, compounds 3, 4 and 5 exhibited recognizable DPPH free radical scavenging potential.Only 3 exhibited weak activity against Herpes simplex virus, whereas 3 and 4 showed cytotoxicity against KB and MCF-7 cancer cells. Conclusion: This study is the first report on the chemical and biological properties of D. williamsonii.Compounds 3, 4 and 5 are responsible for free radical scavenging activity of this plant. Compound 4 showed the strongest cytotoxic effect on KB cancer cells.

Key words:Dendrobium williamsonii, Orchidaceae, Anti-herpetic Cytotoxicity, Free radical scavenging activity.

}, keywords = {Anti-herpetic Cytotoxicity, Dendrobium williamsonii, Free Radical Scavenging Activity, Orchidaceae}, author = {Pathrapa Rungwichaniwat and Boonchoo Sritularak and Kittisak Likhitwitayawuid} }