@article {1429, title = {Fenugreek (Trigonella Foenum-Graecum) and its Active Compounds: A Review of its Effects on Human Health through Modulating Biological Activities}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {May 2021}, pages = {813-821}, type = {Review Article}, chapter = {813}, abstract = {

Fenugreek seed are rich sources of various essential compounds and such components shows a significant role in the diseases cure and management through its anti-inflammatory, hepatoprotective, cardioprotective, neuroprotective, immunomodulatory, nephroprotective and anti-microbial activity. Moreover, fenugreek seed is a rich source of antioxidant and such potentiality inhibit the pathogenesis of diseases through free radical scavenging activity. Besides, fenugreek and its active compound shows role in tumour inhibition through modulating various genes activity including induction of apoptosis, tumour suppressor gene and inhibition of tumor necrosis factor. This review comprehensively summarizes the role of fenugreek seeds in health management through modulating various physiological and biochemical activities, along with special emphasis on in vitro and in vivo study.

}, keywords = {Anti-cancer activity, Anti-inflammatory, Anti-oxidant, Fenugreek, Health management, Trigonella foenum-graecum}, doi = {10.5530/pj.2021.13.103}, author = {Saleh A Almatroodi and Ahmad Almatroudi and Mohammed A Alsahli and Arshad Husain Rahmani} } @article {498, title = {Maltase Inhibitory Activity of Aqueous Extracts of Zingiber officinale Rosc. and Trigonella foenum-graecum Linn.}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {January 2018}, pages = {226-229}, type = {Original Article}, chapter = {226}, abstract = {

Context: An important approach to diabetes treatment involves the regulation of postprandial hyperglycemia by delaying the release of glucose into the bloodstream using inhibitors for carbohydrate digesting enzymes such as maltase. Current synthetic antidiabetic drugs are associated with side effects that have restricted their usage. Antidiabetic plants such as Zingiber officinale and Trigonella foenum-graecum, commonly used as medicinal herbs in India, provide an attractive alternative as a source of maltase inhibitors. Aim: This study aimed to determine maltase inhibitory activity in antidiabetic plants in comparison with that of a synthetic drug, Acarbose, used as a positive control. Study Design: In vitro Enzyme Inhibition Assay. Materials and Methods: Aqueous plant extracts were prepared using rhizome of Z. officinale and leaves of T. foenum-graecum. Varying concentrations of the aqueous plant extract were tested for maltase inhibitory activity using crude yeast maltase enzyme. Statistical Analysis: Unpaired, two tailed t-test was used to detect the significant difference between the mean maltase enzyme activity of the control and that of the test. Results: The aqueous extract of T. foenum-graecum exhibited a higher potent maltase inhibitory activity with IC50 value of 1.05\% as compared to that of the aqueous extract of Z. officinale with IC50 value of 2.13\%. Acarbose showed the highest potency of maltase inhibition with an IC50 value of 0.014\%. Conclusion: Z. officinale and T. foenum-graecum have significant maltase inhibitory activity (p \<0.05). Thus, a contributing factor to the antidiabetic property of the two plants may be attributed to their maltase inhibitory activity.

}, keywords = {Acarbose, Antidiabetic Plants, Maltase Inhibitory Activity, Trigonella foenum-graecum, Zingiber officinale}, doi = {10.5530/pj.2018.2.39}, url = {http://fulltxt.org/article/469}, author = {Janhavi Jatin Damani and Radiya Pacha-Gupta and Nandita Mangalore} }