@article {1402, title = {Metformin Potentiates the Antidiabetic Properties of Annona muricata and Tapinanthus globiferus Leaf Extracts in Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {May 2021}, pages = {614-619}, type = {Original Article}, chapter = {614}, abstract = {

Background: There is paucity of experimental evidence on the complementary use of standard anti-diabetic drugs with herbal formulations. Materials and Methods: In this study, extracts of Annona muricata (AME) and Tapinanthus globiferus (TGE) were administered with metformin to diabetic rats in order to study the potential complementary effects. Diabetes was induced by a single intraperitoneal (i.p) injection of alloxan (150 mg/kg BW). AME and TGE (200 mg/ kg BW each) and Metformin (100 mg/kg BW) was administered to diabetic rats orally for 21 days. At the end of the study, rats were sacrificed; blood was collected for assessment of lipid profile and kidney function. Results: Treatment of diabetic rats with AME and TGE caused a significant decrease (p \< 0.05) in the concentrations of total cholesterol (TC), triglyceride (TG) and Coronary Risk Index (CRI) with a concomitant increase in High Density Lipoprotein (HDL). Similarly, urea and creatinine concentration decreased in diabetic rats administered plant extracts. Co-administration of the plant extracts with metformin significantly improved lipid profiles and kidney function relative to rats administered metformin alone. Co-administration of AME and TGE extracts with metformin produced significant improvement in biochemical indices of diabetic rats. Conclusion: The results suggest potential synergistic interaction between the plant extracts and metformin. Furthermore, this work provides scientific support for the concomitant use of the plants used in the study with orthodox drugs for the management of diabetes.

}, keywords = {Annona muricata, Diabetes, Drug interaction, Tapinanthus globiferus}, doi = {10.5530/pj.2021.13.77}, author = {Francis O. Atanu and Oghenetega J. Avwioroko and Omotayo B. Ilesanmi and Ojochenemi E. Yakubu} } @article {511, title = {Pharmacodynamic and Pharmacokinetic Interactions of Piperine on Gliclazide in Animal Models}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {January 2018}, pages = {221-225}, type = {Original Article}, chapter = {221}, abstract = {

Back Ground: The objective of the present study was to find out the pharmacodynamic and pharmacokinetic interactions of piperine on gliclazide in rats and rabbits. Methods: Influence of piperine on the activity of gliclazide was determined by conducting single- and multipledose interaction studies in rats (normal and diabetic) and diabetic rabbits. Blood samples collected at predetermined time intervals from experimental animals were used for the estimation of glucose and insulin levels by using automated clinical chemistry analyzer and radioimmunoassay method, respectively. \β-cell function was determined by homeostasis model assessment. Additionally, serum gliclazide levels in rabbits were analyzed by highperformance liquid chromatography. Results: Gliclazide showed significant reduction in blood glucose levels in diabetic rats and rabbits. Similarly, piperine also showed significant reduction in blood glucose levels in animals. Additionally, , samples analyzed from all time points in combination with piperine showed peak reduction in blood glucose in diabetic rats and rabbits. The pharmacokinetics of gliclazide was also altered by single- or multiple-dose piperine treatments in rabbits. Conclusion: The interaction of piperine with gliclazide upon single and multiple-dose treatment was pharmacodynamic and pharmacokinetic in nature, indicating the need for periodic monitoring of glucose levels and dose adjustment as necessary when this combination is prescribed to diabetic patients.

}, keywords = {Diabetes, Drug interaction, Gliclazide, Piperine}, doi = {10.5530/pj.2018.2.38}, url = {http://fulltxt.org/article/468}, author = {Umachandar Lagisetty and Habibuddin Mohammed and Sivakumar Ramaiah} }