@article {937, title = {Antiosteoporosis Effects of 70\% Ethanolic Extract Combination of Dayak Onion Bulbs (Eleutherine bulbosa (Mill.) Urb) and Cowpea (Vigna unguiculata (L.) Walp.) on the Hypoestrogen Rats}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {July 2019}, pages = {632-638}, type = {Original Article}, chapter = {632}, abstract = {

Introduction: Cowpea and Dayak onion bulbs extracts were proven to have an effect on bone, cause by the content of daidzein and eleutherinol which has been known to have an affinity to bind with estrogen receptor selectively. The objective of this study to determine the effects of Dayak onion bulbs and cowpea extract combination on the level of bone calcium, bone weight, and the scoring of bone marrow fat in the hypoestrogen rats compared with the single dose of cowpea extract. Material and Methods: This study used 32 female, white Sprague-Dawley rats were divided into eight groups. The SHAM group was given CMC 0.5\%; the negative group was given CMC 0.5\%, the positive group was given raloxifene 1.08 mg/200 g BW, cowpea group was given cowpea extract 100 mg/200 BW. The dose variation was given 70\% ethanolic extract combination of Dayak onion bulbs and cowpea with four doses variation 36 mg/200 g; 100 mg/200 g BW, 18 mg/200 g; 100 mg/200 g BW, 9 mg/200 g; 100 mg/ 200 g BW, and 4.5 mg/200 g; 100 mg/200 g BW. Ovariectomy was performed on all groups except the SHAM to obtain the condition of hypoestrogen. Four weeks after the surgery, the rats were treated with an oral administration of extract daily for 28 days. Determination of the levels of tibia bone calcium, tibia bone weight, and the scoring of tibia bone marrow fat counted on day 29. Results: The result showed that Dayak onion bulbs and cowpea extract combination were able to elevate the level of bone calcium and bone weight significantly, and reduced the scoring of bone marrow fat higher than a single dose of cowpea extract. Conclusions: The results showed that Dayak onion bulbs and cowpea extract combination could be developed to be a drug for osteoporosis in the future.

}, keywords = {Antiosteoporosis, Bone calcium, Bone marrow fat, Bone weight, Cowpea, Dayak onion bulbs, Raloxifene}, doi = {10.5530/pj.2019.11.101}, author = {Anton Bahtiar and Renita Dewi} } @article {534, title = {Effects of Dayak Onion Bulbs (Eleutherine bulbosa (Mill.) Urb) on Bone Development of the Hipoestrogen Model Rat.}, journal = {Pharmacog Journal}, volume = {10}, year = {2018}, month = {January-2018}, pages = {299-303}, type = {Original Article}, chapter = {299}, abstract = {

Background: Eleutherinol is a naphtoquinone derivative that has strong affinity to bind with estrogen alpha receptors (ER\α). This compound can be found in Dayak Onion Bulbs (Eleutherine bulbosa Mill.). Objective: The purpose of this study is to analyze the effects of Dayak Onion Bulbs extract on the growth of the bone of hypoestrogen model rat. Methods: A total of 36 female white rats of Sprague-Dawley were divided into 6 groups. All 6 groups receive CMC Na 0,5\% (sham group), CMC Na 0,5\% (negative group), tamoxifen (positive group), three level of dayak onion bulbs extract doses namely dose 8 mg/ 200 g, 12 mg/ 200 g , and 18 mg/ 200 g. All groups, except the sham, is ovariectomized to obtain the conditions of hypoestrogen. After ovariectomy, all rats were evaluated for the success of ovariectomy on day 35, followed by the administration of the extracts by oral administration for 21 days. After 21 days administration, the level of bone calcium, bone weight, and bone length were measured by Atomic Absorption Spectrophotometry. Results: Dayak onion bulbs extract at dose 3 (18 mg/200 g BW) could increase significantly bone calcium level, bone weight, and bone legnth of hypoestrogen rat. Conclusion: The results showed that Dayak onion bulbs extract could be developed to be a drug for menopause woman in the future.

}, keywords = {Bone calcium level, Bone length, Bone weight, Dayak onion bulbs, Hypoestrogen, Menopause}, doi = {10.5530/pj.2018.2.52}, url = {http://fulltxt.org/article/482}, author = {Anton Bahtiar and Riza Annisa} }