@article {1835, title = {Uncover Itchy Leaves Ethnomedicine Usage: A Preliminary Study on Characterization and Bioactivity of Laportea Spp}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {August 2022}, pages = {286-295}, type = {Original Article }, chapter = {286}, abstract = {

Background: Laportea decumana (Roxb.) Wedd. and Laportea stimulans (L.f.) Miq. (Urticaceae) or itchy leaves are endogenous plants from The Maluku Islands, Indonesia, which are used topically as analgesics by local people. Objective: As part of a preliminary investigation on the itchy leaves, this study was conducted to provide information on their macroscopic and microscopic characteristics, phytochemical profiles, and bioactivities according to the ethnomedicinal usages. Materials and Methods: The macroscopic examination was carried out on fresh leaves. The microscopic examination was carried out on leaf powder under a light microscope. The phytochemical analyses using TLC were conducted on those crude extracts and fractions. The bioactivity assays were conducted in vitro as Cox-2 inhibitory and DPPH radical scavenging activities. Results: reveal similar characteristics in the macroscopic and microscopic properties of both Laportea spp. leaves. Calcium oxalate crystals were observed in L. decumana but not found in L. stimulans. Both species have stomata with anisocytic type. More trichomes are found in the leaves of L. decumana, yet smaller and easily detachable. TLC analyses exhibited slightly different profiles. The crude extracts and fractions at 10 μg/ml showed similar inhibitory percentages on Cox-2. The DPPH scavenging activities of the crude extracts and fractions of L. decumana showed active moderate activity with an IC50 value \< 250 μg/ml, while those of L. stimulans showed moderate to weak potency with an IC50 value \< 500 μg/ml. Conclusion: Further exploration on Laportea spp. pharmacological activity is recommended to provide stronger evidence for its ethnomedicinal usage.

}, keywords = {Characterization, Cox-2 inhibitor, DPPH radical scavenging activity., Itchy leaves, Laportea decumana (Roxb.) Wedd, Laportea stimulans (L.f.) Gaud, Phytochemical profiles}, doi = {10.5530/pj.2022.14.98}, author = {Lukman La Basy and Djoko Santosa and Retno Murwanti and Triana Hertiani} } @article {1450, title = {Comparison in Vitro of Antioxidant Activity between Fifteen Campanula Species (Bellflower) from Palestinian Flora}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {29th Apr, 2015}, pages = {9-9}, type = {Original Article}, chapter = {9}, abstract = {

Background: The natural antioxidant products in the plant kingdom play an important role in the healthy life style and reduce the risk for various chronic diseases. Objective: The objective of this study was to investigate different antioxidant pharmacological property of methanol extract for fifteen species of Campanula plant from Palestinian flora. Methods: The antioxidant activity of fifteen Campanula species growing wildly in Palestine were studied using 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging activity and their antioxidant activity was compared to Trolox antioxidant activity. Results: The results clearly demonstrate a very high antioxidant activity of the Campanula sulphurea and Campanula sidoniensis and they showed almost the same antioxidant activity of Trolox. The other twelve species extracts also exhibited excellent antioxidant activity in DPPH radical scavenging activity in comparison with trolox standard. Conclusion: Methanol extract of Campanula can be valuable for treatment of different diseases and could be used as a possible new source of natural antioxidants in the food, nutraceuticals, pharmaceuticals and cosmetic industry.

Key words: Antioxidant, Bellflower, Campanula, Bellflower, Campanulaceae, DPPH radical scavenging activity

}, keywords = {Antioxidant, Bellflower, Campanula, Campanulaceae, DPPH radical scavenging activity.}, author = {Nidal Amin Jaradat and 1Murad Abualhasan} } @article {66, title = {Comparison in vitro of Antioxidant Activity between Fifteen Campanula Species (Bellflower) from Palestinian Flora}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {01/2015}, pages = {276-279}, type = {Original Article}, chapter = {276}, abstract = {

Background: The natural antioxidant products in the plant kingdom play an important role in the healthy life style and reduce the risk for various chronic diseases.Objective: The objective of this study was to investigate different antioxidant pharmacological property of methanol extract for fifteen species of Campanula plant from Palestinian flora. Methods: The antioxidant activity of fifteen Campanula species growing wildly in Palestine were studied using 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging activity and their antioxidant activity was compared to Trolox antioxidant activity. Results: The results clearly demonstrate a very high antioxidant activity of the Campanula sulphurea and Campanula sidoniensis and they showed almost the same antioxidant activity of Trolox. The other twelve species extracts also exhibited excellent antioxidant activity in DPPH radical scavenging activity in comparison with trolox standard. Conclusion: Methanol extract of Campanula can be valuable for treatment of different diseases and could be used as a possible new source of natural antioxidants in the food, nutraceuticals, pharmaceuticals and cosmetic industry.

}, keywords = {Antioxidant, Bellflower, Campanula species, Campanulaceae, DPPH radical scavenging activity.}, doi = {10.5530/pj.2015.5.4}, author = {Nidal Amin Jaradat and Murad Abualhasan} }