@article {351, title = {An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {May 2017}, pages = {504-518}, type = {Original Article}, chapter = {504}, abstract = {

Background: Khaya senegalensis (Desr.) A. Juss. is a common component of the pharmacopeia\’s of multiple African groupings which inhabit the areas in which it grows. Amongst these groups there is a myriad of medicinal uses in the treatment of a wide variety of bacterial, fungal and protozoal infections, as well as in the treatment of cancers. This study was undertaken to test K. senegalensis bark extracts for the ability to inhibit microbial and cancer cell growth, and thus to validate traditional African medicinal usage of this plant in treating a variety of diseases. Materials and Methods: K. senegalensis bark powder was extracted by both solvent maceration and subcritical fluid extraction (SFE). The extracts were tested for the ability to inhibit bacterial and G. duodenalis growth. Inhibition of Caco-2 and HeLa cancer cells was evaluated using MTS-based colorimetric cell proliferation assays. Toxicity was evaluated using an Artemia franciscana nauplii bioassay and GC-MS headspace analysis was used to identify phytochemical components. Results: K. senegalensis bark extracts displayed strong inhibitory activity against bacterial triggers of several autoimmune inflammatory diseases. The growth inhibitory activity of the methanolic and subcritical extracts was particularly noteworthy against P. mirabilis (MIC values of 185 and 211\μg/mL, respectively against the reference strains). These extracts were similarly potent growth inhibitors of K. pneumoniae and A. baylyi\ and were moderate inhibitors (MIC \>1000\μg/mL) of P. aeruginosa and S. pyogenes growth. The methanolic and subcritical K. senegalensis extracts were also potent inhibitors of G. duodenalis (187 and 328\μg/mL, respectively), as well as Caco-2 (268 and 470\μg/mL, respectively) and HeLa carcinomas (155 and 174\μg/mL, respectively). GC-MS analysis of the SFE extract revealed relative abundances of a variety of mono- and sesquiterpenoids. Furthermore, all K. senegalensis bark extracts were non-toxic in the Artemia franciscana toxicity assay, indicating their safety for therapeutic use. Conclusion: These studies validate traditional African therapeutic usage of K. senegalensis in the treatment of microbial infections, autoimmune inflammatory diseases and some cancers.

}, keywords = {African mahogany, Anti bacterial activity, Anti-cancer activity, Anti-proliferative activity, Giardia duodenalis, Meliaceae, Sub-critical fluid extraction, Terpenoid.}, doi = {10.5530/pj.2017.4.82}, url = {/files/PJ-9-4/10.5530pj.2017.4.82}, author = {Camille Rabadeaux and Lou Vallette and Joseph Sirdaarta and Craig Davis and Ian Edwin Cock} } @article {67, title = {Abutilon indicum L (Malvaceae)-Medicinal Potential Review}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {Nov-Dec 2015}, pages = {330-332}, type = {Review Article}, chapter = {330}, abstract = {

The plant Abutilon Indicum (Linn.) is belonging to malvaceae family; Also known as Mallow in english, Abutilon indicum is used as a medicinal plant. It has been reported that Abutilon indicum has Anti inflammatory and Antiproliferative activity, Anti-Arthritic activity, Analgesic and Sedative property, Antioxidant and Antimicrobial activity, Hepatoprotective activity, Anti diabetic, Anti cancer, Anti diarrhoeal, Anti-convulsant, Larvicidal, Wound healing, Anti asthmatic, Diuretic, Immunomodulatory, and Anti-estrogenic activity. It is proved that this plant contains carbohydrates, proteins and aminio acids, saponins, flavanoids, glycosides, phytosterols and phenolic compounds

}, keywords = {Abutilon indicum, Anti asthmatic, Anti-proliferative activity, Hepatoprotective activity, Phenolic compounds}, doi = {10.5530/pj.2015.6.2}, author = {Rajagopal Ramasubramania raja and Koumara Velou Kailasam} }