@article {2132, title = {Analysis of Policy Implementation of Minimum Service Standards for Hypertension in Marusu Health Center Maros District}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {October 2023}, pages = {861-867}, type = {Research Article}, chapter = {861}, abstract = {

The Minimum Service Standards (SPM) in the health sector are a reference for Regency/City. Regional Governments in the provision of Health Services that every citizen is entitled to receive at a minimum. The MSS for Hypertension health services is one of the types and quality of basic services in the MSS in the health sector. This study aims to analyze the implementation of the MSS for hypertension services at the Marusu Health Center, Maros Regency. This type of research uses descriptive qualitative which aims to get an in-depth description of the analysis of the implementation of the minimum service standard for hypertension at the Marusu Health Center. The results of the study show that communication has not run optimally, the SPM Hypertension policy contained in PMK No. 4 of 2019 has not been transmitted to the public as a policy target. Human resources are still inadequate and have a double workload so that the achievements are not optimal. Disposition has been going pretty well. commitment and implementation support are quite good, has carried out coordination and commitment involving cross-programs and related cross-sectors. The bureaucratic structure is already running quite well. The implementation mechanism has been running according to the SOP with the guidelines of the Minister of Health Regulation No. 4 of 2019. The implementation of the SPM for hypertension services at the Marusu Health Center has been going quite well. It is hoped that the Maros District Health Office and the Marusu Health Center will improve the aspects of communication, resources, disposition and bureaucratic structure in their implementation.

}, keywords = {Commitment., Hypertension, Minimum services, Policy implementation}, doi = {10.5530/pj.2023.15.165}, author = {Wafika Aziza Nasir and Sukri Palutturi and Alwy Arifin and Balqis and Wahiduddin and Anwar Daud and Anwar Mallongi} } @article {1220, title = {Anti-Hypertensive Activity of Punica granatum peels Ethyl Acetate Extract on Fludrocortisones Induced Hypertension in Wistar Rats}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {August 2020}, pages = {1135-1142}, type = {Research Article}, chapter = {1135}, abstract = {

Pomegranate (Punica granatum Linn.) has several medicinal properties. Pomegranate juice has been reported to be an effective source of high amounts of phyto-constituents with many health and nutritional benefits. This work assessed the possible effect on blood pressure (B.P) and heart rate of P. granatum peel ethyl acetate extract (PGE) at a dosage of 400 mg / kg / day on hypertension-induced fludrocortisone Wistar rats. PGE therapy substantially lowered the B.P of hypertensive rats treated with salt fludrocortisones, but the mean blood pressure and heart rate in normotensive rats were not altered. In isolated aortic strip, the contractile reactions to noradrenalin of PGE-treated hypertensive rats have been substantially reduced. The active fraction was purified by successive chromatographic techniques resulted in isolation of quercetin and ursolic acid, this bioactive mixture induced a significant decrease in the blood pressure of hypertensive rats as compared to hypertensive control rats at a concentration of 10 mg/kg.

}, keywords = {Hypertension, Punica granatum, Quercetin, Ursolic acid}, doi = {10.5530/pj.2020.12.160}, author = {Rafik Monir and Asmaa S Abd Elkarim and Mohamed Fouad Shalaby and Alsayed Ahmed Zaki and Samah Shabana} } @article {1154, title = {Characteristics of Turbinaria conoides and Padina Minor As Raw Materials For Healthy Seaweed Salt}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {May 2020}, pages = {624-629 }, type = {Research Article}, chapter = {624}, abstract = {

Background: Seaweed is one of the abundant biological resources in Indonesia and contains secondary metabolites. This study was aimed to determine the characteristics and antioxidant activity of brown seaweed salts that fits the standard hence it can be applied as a functional salt preparation for hypertensive patients. Objective: The study consisted of identification of raw materials, yield analysis, the levels of Na and K, heavy metals, NaCl and antioxidant activities using the Ferric Reducing Antioxidant Power (FRAP) and the Cupric Reducing Antioxidant Capacity (CUPRAC) methods. Materials and Methods: The experimental design used was a Completely Randomized Design (CRD) with different types of seaweed as a parameter (Turbinaria conoides and Padina minor), temperature (400C and 550C), and time (10 and 30 minutes) with 3 replications. Results: The results demonstrated the interaction between different types of seaweed, temperature and heating time had a significant effect on the level of 5\% (P \< 0.05) on yield, the ratio of Na:K and functional salt NaCl. A functional salt FRAP antioxidant activity of T. conoides ranged from 39.12 to 55.31 μM trolox/g and CUPRAC ranged from 98.50 to 113.95 μM trolox/g, while the functional salt from P. minor has FRAP antioxidant activity ranging from 18.19 to 24.67 {\textmu}M trolox/g and CUPRAC 40.05-53.05 {\textmu}M trolox/g. Conclusion: Seaweed T. conoides and P. minor can be used as raw materials for functional salt preparations for hypertensive patients.

}, keywords = {CUPRAC, DPPH, FRAP, Functional salt, Hypertension}, doi = {10.5530/pj.2020.12.93 }, author = {Nurjanah and Asadatun Abdullah and Seftylia Diachanty} } @article {616, title = {Acute and Sub-Acute Antihypertensive Effects of Syzygium polyanthum Leaf Extracts with Determination of Gallic Acid using HPLC Analysis}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {June 2018}, pages = {663-671}, type = {Original Article}, chapter = {663}, abstract = {

Context: Aqueous decoction of Syzygium polyanthum (ADSP) leaf is one of Malay traditionalremedial- preparations for hypertension. Intravenous ADSP reduced blood pressure of anesthetized Wistar-Kyoto (WKY) and Spontaneously-Hypertensive rats (SHR); however, acute and sub-acute effects of oral ADSP on conscious rats and its bioactive compound(s) are not comprehensively studied. This study aims to examine the acute and sub-acute effects of ADSP in comparison to methanol extract (MESP) on systolic blood pressure (SBP) of conscious WKY and SHR rats, as well as to identify their major phenolic-compound using highperformance- liquid-chromatography (HPLC). Methodology: For acute study, SHR and WKY rats were gavaged with single-dose of ADSP or MESP (2.00, 2.50 or 3.00 g/kg), vehicles, or losartan (0.01 g/kg). SBP was measured after 1, 3, 5, 6 and 24 hr-post-administration. For subacute experiment, SHR rats were gavaged once-daily with ADSP or MESP (2.50 g/kg/day), vehicles, or losartan (0.01 g/kg/day) for 3-week and their SBP was weekly-measured. Phenolic compounds were screened using ferric-chloride test, then gallic acid was determined using HPLC. Results: Acute administration of ADSP (2.50 to 3.00 g/kg) and MESP (2.00 to 3.00 g/ kg) significantly reduced SBP of SHR, but not of WKY rats. Repeated-daily-dose administration of MESP (2.5 g/kg/day) significantly reduced SBP of SHR after 2-week and sustained until 3-week, while ADSP (2.5 g/kg/day) significantly reduced SBP only after 3-week. Gallic acid was the major phenolic-compound in ADSP (157.09 \± 4.18 ppm) and MESP (134.04 \± 10.30 ppm). Conclusion: Oral ADSP and MESP that contain gallic acid possess acute and sub-acute antihypertensive effects in SHR, but MESP\’s effect was more prominent than ADSP

}, keywords = {Antihypertensive, Gallic acid, HPLC, Hypertension, Syzygium polyanthum}, doi = {10.5530/pj.2018.4.109}, url = {http://fulltxt.org/article/647}, author = {Azlini Ismail and Nurul Syahida Ramli and Mahaneem Mohamed and Wan Amir Nizam Wan Ahmad} } @article {464, title = {Angiotensin-Converting Enzyme Inhibition of Fractions from Eleusine indica Leaf Extracts}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {December 2017}, pages = {25-28}, type = {Original Article}, chapter = {25}, abstract = {

Solvent fractions and decoction of Eleusine indica leaves were tested for their ability to inhibit angiotensin-converting enzyme (ACE), an important component of the Renin-Angiotensin- Aldosterone System which is a critical regulator of arterial blood pressure. The ACE inhibitory activity of each fraction was measured by employing a colorimetric assay based on the hydrolysis of histidyl-hippuryl-leucine (HHL) by ACE. Preliminary assay results revealed that the ethyl acetate fraction exhibited the highest antihypertensive activity with a percent inhibition of 51.51\%. This fraction was considered for further isolation using a bioassay-guided fractionation scheme.

}, keywords = {Bioactive extracts, High-blood pressure, Hypertension, Medicinal, Plant extracts}, doi = {10.5530/pj.2018.1.5}, url = {http://fulltxt.org/article/360}, author = {Jasmin T Tutor and Christine L Chichioco-Hernandez} } @article {71, title = {Anti Hypertensive Activity of the Ethanolic Extract of Lantana camara leaves on high salt loaded wistar albino rats}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {01/2015}, pages = {289-295}, type = {Original Article}, chapter = {289}, abstract = {

Background: Hypertension is the most common and major cardiovascular disease. There is an urgent need for treament of hypertension by exploration of several medicinal plants having potent anti hypertensive activity as the modern medicines are having many side effects. Objective: The study focus on scientific evaluation of antihypertensive activity of ethanolic extract of Lantana camara leaves (EELC) in different experimental models. Material \& methods: Antihypertensive activity was conducted on wister albino rats by determining serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), creatinine and Sodium levels by using Semi Autoanalyser and Flame photometer; chick mean arterial blood pressure by using condon\’s mercury manometer and isolated frog heart for recording cardic responses using student kymograph. Results: EELC produced negative inotropic and negative chronotropic effect, antagonised by atropine on isolated frog heart. EELC shows dose dependent (p\<0.05) decreased mean arterial blood pressure (MABP) in anaesthetic chick. Salt treated rats displayed significant (p\<0.05) increase in blood level of SGOT, SGPT, Creatinine and sodium, decrease in pottassim levels in comparision with normal rats. Treatment with EELC (200 and 400 mg/kg) significantly balanced the ionic levels such as lower the sodium and elevate the potassium levels. Creatinine levels were signifi-cantly (p\<0.05) reduced by the treatment with EELC. There are no significant changes occurred in serum SGOT and SGPT upon EELC administration. The present study suggests that treatment of salt hypertensive rats with EELC protects against renal injuries. Conclusion: It was concluded that ethanolic extract of Lantana camara leaves reduces work load of heart, maintain inotonic levels by negative chronotropic effect, relaxes the smooth muscles in chick and salt hypertensive rats against renal and vascular injuries is proved.

}, keywords = {EELC (Ethanolic extract of Lantana camara leaves), Hypertension, Mean arterial blood pressure (MABP) and Normotensive rats (NTR)., Wistar albino rats}, doi = {10.5530/pj.2015.5.7}, author = {Vijay Kumar Matta and Praveen Kumar Pasala and Silvia Netala and Satish Pandrinki and Prasad Konduri} } @article {1435, title = {Anti Hypertensive Activity of the Ethanolic Extract of Lantana camara leaves on high salt loaded wistar albino rats}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {9th June 2015}, pages = {3-3}, type = {Original Article}, chapter = {3}, abstract = {

In an attempt to scientifically evaluate the antihypertensive activity of etanolic extract of Lantana camara in different experimental models. Anti hypertensive activity of EELC was evaluate by frog heart, anaesthetic chick and salt induced rat model. EELC produced negative inotropic and negative chronotropic effect, antagonised by atropine on isolated frog heart. EELC shows dose dependent (p\<0.05) decreased mean arterial blood pressure (MABP) an anaesthetic chick. salt treated rats displayed significant (p\<0.05) increase in blood level of SGOT,SGPT, Creatinine and sodium, decreases in pottassim levels compare than normal rats. Treatment of EELC (200 and 400 mg/kg) significantly balanced the ionic levels, such as lower the sodium and elevate the potassium levels. Creatinine levels were significantly (p\<0.05) reduces by the treatment of EELC. These are no significant changes occurred in serum SGOT and SGPT with the treatment of EELC. The present study suggest that treatment of EELC on Salt hypertensive rats protects against renal injuries maintaining the normal ionic composition as well as parameters.

Key words: EELC (ethanolic extract of Lantana camara leaves), Wistar albino rats, Hypertension, mean arterial blood pressure (MABP) and normotensive rats (NTR).

}, keywords = {EELC (Ethanolic extract of Lantana camara leaves), Hypertension, Mean arterial blood pressure (MABP) and Normotensive rats (NTR)., Wistar albino rats} }