@article {1398, title = {Cardioprotective Role of Partharishtam on Isopreterenol Induced Myocardial Infarction in Animal Model}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {March 2021}, pages = {591-595}, type = {Research Article}, chapter = {591}, abstract = {

Myocardial infarction (MI) is one of the key causes of high death rate globally. We report the cardio protective effect of an Ayurvedic polyherbal formulation Partharishtam on isoproterenol induced myocardial infarction on albino rats. Administration of Isoproterenol to normal albino rat triggers MI evident from the significant changes in key biomolecules tested in blood serum and cardiac tissues. The cardio protective role of Partharishtam was compared with a standard medicine, Propranolol on some of the known identifying markers of MI such as, Troponin I and T, creatine phosphokinase serum (CPK-S), creatine phosphokinase myoglobulin isozyme fraction (CPK-MB) and oxidative enzymes like super oxide dismutase (SOD), reduced glutathione (GSH) and catalase. There was an appreciable decrease in the levels of Troponin 1 and T, CPK-S and CPK-MB after the treatment of Partharishtam on Isoproterenol induced MI rats. In vivo anti-oxidative enzyme studies also revealed the increase in the levels of SOD, GSH and catalase to near normalcy after the treatment of Partharishtam in MI rats, which is very much comparable to the commonly used drug Propranolol to treat MI patients. Histopathological analysis confirmed the cardio protective properties of Partharistham in rat model. We did not find any side effects or toxicity of Partharishtam when tested on the normal rats. Thus, polyherbal formulation Partharishtam could be considered as safe medicine for MI.

}, keywords = {Catalase, Creatine phosphokinase, GSH, Isoproterenol, Myocardial Infarction, Partharishtam, Polyherbal, Propranolol, SOD, Troponin I, Troponin T}, doi = {10.5530/pj.2021.13.74}, author = {G. Narayanan and K Prabhu and Anath Bandhu Chaudhury and Mudiganti Ram Krishna Rao and V S Kalai Selvi and N S Muthiah and Sruthi Dinakar} } @article {906, title = {Exploration of Anti-Urolithiasis Potential of Traditional Siddha Formulations Amukkara Chooranam and Karisalai Karpam Chooranam by Struvite Crystal Growth Inhibition Assay}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {July 2019}, pages = {683-688}, type = {Original Article}, chapter = {683}, abstract = {

Background: Urolithiasis is a medical condition characterized by formation of stone which comprises of calcium oxalate, magnesium ammonium phosphate and uric acid. Reoccurrence becomes the primary hindering factor in providing relief for urolithiasis; hence there is a need of alternate therapeutic strategy that may effectively combat and halt the formation and nucleation of the crystals. Objective: The main aim of the present investigation is to explore the anti-urolithiasis potential of the two versatile siddha formulations Amukkara Chooranam (AKC) and Karisalai Karpam Chooranam (KKC) using diffusion gel growth technique. Materials and Methods: Silica hydrogel matrix was divided in to three groups which were control, AKC and KKC treated groups. Test drugs were screened at two dose levels of 0.5\% and 1\%. The efficiency of the formulations was screened by comparing the crystal size of the control and treatment medium. Results: The average size of the crystals in the control medium was found to be 2.12 {\textpm} 0.22 cm, whereas the crystal size was significantly decreased in medium contains 0.5\% and 1\% of AKC with the size of 1.4 {\textpm} 0.15 and 1.14 {\textpm} 0.18 cm. Similar type of findings were observed in medium consist of 0.5\% and 1 \% KKC with the size of 1.52 {\textpm} 0.13 and 1.08 {\textpm} 0.17 cm. Conclusion: Results clearly indicates that both the siddha formulations offers maximum percentage inhibition on the crystal growth in the tested medium, this efficacy may be due to presence of versatile phytocomponents present in the formulations.

}, keywords = {Amukkara Chooranam, Crystals, Karisalai karpam chooranam, Lithotripsy, Polyherbal, Traditional medicines}, doi = {10.5530/pj.2019.11.108}, author = {D.Sivaraman and N.Anbu and N.Kabilan and M.Pitchiah Kumar and P.Shanmugapriya and G.J.Christian} } @article {800, title = {Mineral Content Analysis of Polyherbal Energy Bar Using X-Ray Fluorescence Technique}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {January 2019}, pages = {53-56}, type = {Original Article}, chapter = {53}, abstract = {

Aim: The objective of the present study was to develop a novel energy bar which is nutritious and cost effective. Materials and Methods: The components used for the novel energy bar were banana, orange, peanuts, raisins, cocoa butter, stevia leaves and oats. Mineral contents of energy bar were analysed by XRF technique. Results: The mineral contents were present in comparable amount. Major elements viz. K 17.15\%, P 4.57\%, Mg 1.43\%, Ca 0.93\%, Na 0.66\%, S 0.54\%, Fe 0.15\%, Zn 0.05\% and Cu 0.02\% were present in energy bar. Conclusion: Minerals are good for overall growth of body. The energy bar also contains no preservatives, binding agents and sugar free. So, the energy bar is major source of energy and minerals for all age group individuals.

}, keywords = {Calcium, Energy bar, Iron, Mineral content, Polyherbal, Potassium}, doi = {10.5530/pj.2019.1.10}, author = {Mansi Chitkara and Rajneet Kohli and Inderjeet Singh Sandhu and Didar Singh and Gagandeep Kaur and Rakesh Kumar Sindhu} } @article {688, title = {Physicochemical Standardization of Polyherbal Powder Formulation: Safoof-e-Makhana}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {August 2018}, pages = {899-906}, type = {Original Article}, chapter = {899}, abstract = {

Introduction: Safoof-e-Makhana (SM) is a Unani polyherbal powder formulation used to treat Sexual disorders. Formulation consists of following herbs Orchis latifolia, Hygrophila auriculata, Asparagus racemosus and Elettaria cardamomum. The main aim of this study was to standardize Safoof-e-Makhana (SM), on the basis of organoleptic characters and physico-phytochemical analysis. Methods: The drugs were cleaned, dried in shade and powdered by passing through sieve $\#$ no. 80 as per the method described in UPI / National Formulary of Unani Medicine. This Safoof formulation was evaluated using physicochemical tests: powder characterization, extractive value, alcohol and water soluble matter, Ash value, LOD at 1050C, pH and HPTLC fingerprinting. Statistical analysis used: Mean \± SEM. Results: Organoleptic characters of the formulation are light brown colour, characteristic odour, sweet taste and moderately fine texture. Physicochemical parameters displayed water soluble extractive (21.83 \± 0.08), alcohol soluble extractive (7.87 \± 0.09), total ash (4.76 \± 0.08), acid insoluble ash (3.36 \± 0.01), water soluble ash (0.89 \± 0.25), LOD at 105oC (11.38 \± 0.34), pH of 1\% and 10\% solution were 6.6 \± 0.1 and 6.0 \± 0.1 respectively. Phytochemical qualitative analysis displayed presence of alkaloids, tannins, flavanoids, steroids, terpenoids, carbohydrates, volatile oil. HPTLC fingerprinting data was also set in. Conclusion: The standardization of this formulation was done and the data obtained would be used as a standard for future reference.\ 

}, keywords = {Formulation, Physicochemical, Polyherbal, Powder, Safoof-e- Makhana, standardization, Unani Medicine}, doi = {10.5530/pj.2018.5.151}, author = {Gazi Jahangeer Rather and Hamiduddin and Mohd Ikram, Shaista Fatima and MD Naquibuddin} }