@article {1625, title = {Anti-Inflammatory Activity of Cinnamon Bark Oil (Cinnamomum burmannii (Nees \& T. Nees) Blume from Lombok Timur Indonesia}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {July 2021}, pages = {1005-1013}, type = {Research Article}, chapter = {1005}, abstract = {

Introduction: Research related to alternative medicine from natural ingredients that can relieve the effects of inflammation is important, especially to reduce the unwanted side effects of antiinflammatory drugs. Cinnamomum burmannii (Nees \& T. Nees) Blume is a native Indonesian species which contains essential oils and reported for its anti-inflammatory effect. Therefore, this research was conducted to determine the metabolite profile and anti-inflammatory effect of essential oil from the bark of C. burmannii (CBO) from Lombok Timur Regency. Methods: The metabolite profile of CBO was determined using Gas Chromatography-Mass Spectra (GCMS). The anti-inflammatory test was conducted used male Wistar rats. A total of 30 male rats were divided into 5 groups, each group consisting of 6 rats. Rats were injected with carrageenan 1\%/100μl/paw which had previously been given oral CBO at a dose of 30, 60, 90 mg/kg BW. Paw swelling was measured at 1, 2, 3, 4 and 5 hours after injection. The volume of edema was measured and the animals were sacrificed. The left leg was cut and preserved as material for Hematoxylin Eosin (HE) and Immunohistochemistry (IHC) preparations. The variables taken were the percentage of inhibition edema, the number of inflammatory cells by HE and the amount of TNF-α by IHC staining. Results: The results showed that there was a difference between negative control and positive control in the number of inflammatory cells and TNF-α observed in rat{\textquoteright}s paw edema. The number was less in the positive control. Likewise, when administering CBO (60 mg/kg BW and 90 mg/kg BW) the number of inflammatory cells and TNF-α was lower than the negative control. Conclusion: It can be concluded that CBO from Lombok Timur can be used as a natural anti-inflammatory agent.

}, keywords = {Cinnamomum burmannii, Immunohistochemical staining, Inflammatory cells, Metabolites profile, TNF-α}, doi = {10.5530/pj.2021.13.130}, author = {Budiastuti and Rosy Dwi Nurcholida and Riesta Primaharinastiti and Sukardiman} } @article {700, title = {Identification by Docking Simulation and in vivo Effect of Essential Oil from Cinnamommum burmannii as Anti-obesity with Leptin Receptor in the Olfactory System of Mice Balb C}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {August 2018}, pages = {875-879}, type = {Original Article}, chapter = {875}, abstract = {

Aim: This study examines the effect of inhalation of essential oil of cinnamon (Cinnamomum burmannii) on the metabolic activity of hormone receptors olfactory system of mice Balb C. Methodology: Effects of agonist or antagonist compounds in cinnamon essential oil on metabolic hormone receptors in the olfactory system are predicted using molecular docking simulation. Changes in the metabolic processes that occur views of changes in body weight, change in food intake, as well as lipid profile and blood glucose of mice. Result: The results showed Expression of leptin receptors (Lep-R) in the brains of mice given either inhalation of essential oils derived from the leaves and stems, in contrast to the control group who did not get essential oils. Provision of essential oils through inhalation increased lep-R expression in the brain of mice. Both in silico and in vivo evidence that essential oils from cinnamon plants are extracted from Cinnamommum burmannii and given by inhalation in Balb C mice are known to improve glucose and lipid metabolism by reducing the concentration of serum leptin concentrations and increased sensitivity to insulin.

}, keywords = {Cinnamomum burmannii, docking simulation, immunohistochemistry, leptin receptors, olfactory system}, doi = {10.5530/pj.2018.5.147}, author = {Kusmardi Kusmardi and Aryo Tedjo and Fadilah Fadilah and Ade Arsianti and Rafika Indah Paramita} }