@article {1345, title = {Beneficial Effects of Sambucus nigra in Chronic Stress-Induced Neurobehavioral and Biochemical Perturbation in Rodents}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {January 2021}, pages = {155-161}, type = {Research Article}, chapter = {155}, abstract = {

Background: Stress is the causative factor for various diseases and disorders faced by the majority of the diseased population. The leaves of Sambucus nigra (S. nigra) are attributed to neuropharmacological properties as per literature. Considering the above, the S. nigra hydroalcoholic extract was tested for adaptogenic activity in animals. Objective: The study deals with the evaluation of S. nigra hydroalcoholic extract for adaptogenic activity using cold immobilization and footshock induced stress. Materials and Methods: The S. nigra hydroalcoholic extract (200 and 400 mg/kg) was administered to treatment groups 1 hour before footshock for 14 consecutive days and cold immobilization stress for 10 consecutive days, respectively. The current work was carrying out to investigate the adaptogenic activity of S. nigra against footshock stress induced perturbations in behaviour (sexual behaviour, depression, and cognitive dysfunction). Suppressed male sexual behaviour, percentage active avoidance response and duration of immobility in footshock stress were used as the stress indices. Additionally, liver function (SGOT, SGPT, and ALP), lipid profiles (TC, TG, HDL, LDL, and VLDL) and differential leukocytes counts (neutrophils, eosinophils, lymphocyte, and monocyte) in cold immobilization stress were assessed in terms of stress indices. Diazepam (1 mg/kg) was served as the standard adaptogenic agent as per literature review for comparison. Results: All these chronic stress-induced perturbations were reversed, dose-dependently by S. nigra (2000 and 400 mg/kg) and diazepam (1 mg/kg). The dose group 400 mg/kg p.o. of S. nigra hydroalcoholic extract for adaptogenic activity in cold immobilization and footshock induced stress method showed significant variation (P\< 0.1) when is compared with the stress control group. Conclusion: S. nigra hydroalcoholic extract showed significant adaptogenic activity was indicated by qualitatively results comparable to diazepam, against a range of biochemical and behavioural perturbations induced by chronic stress.

}, keywords = {Active avoidance response, Cold immobilization, Footshock induced stress, Lipid profiles, Sambucus nigra, Sexual behaviour}, doi = {10.5530/pj.2021.13.22}, author = {Sachin Neekhra and Himani Awasthi and Dharmchand Prasad Singh} } @article {710, title = {Effects of Asparagus racemosus Root Extracts on Serum Lipid Profiles, Lipid Peroxidation and Superoxide Dismutase in Ovariectomized Rat}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {August 2018}, pages = {1036-1041}, type = {Original Article}, chapter = {1036}, abstract = {

Background: Once rats have been ovariectomized they have a high risk of cardiovascular disease due to changes in the blood cholesterol and lipid profile. Objective: To investigate the effects of Asparagus racemosus (AR) root extract on the serum lipid profiles, lipid peroxidation and antioxidant levels in ovariectomized rats. Methods: Twenty-five, two month-old female Wistar rats were randomly divided into five groups: SH, OVX,OEE, OAAR and OEAR. The daily doses of 500 mg/KgBW of the AR root extracts for five weeks.The levels of serum TG, TC, HDL, LDL, the liver, kidney and uterine tissue lipid peroxidation and SOD levels were determined. Results: Serum TC and LDL showed no significant differences in any groups. Serum TG of the OAAR and OEAR groups were not significantly different. The serum HDL of the OAAR and OEAR groups were significantly lower than the OEE group. The liver MDA levels of the OAAR and OEAR groups were significantly decreased compared with the OVX and OEE groups while the SOD level of the OAAR group was significantly increased. The MDA levels in the kidney and uterine of the treated group showed no significant difference. The SOD levels in the kidney of the treated group were not different but the SOD levels in uterine were significantly decreased. Conclusion: It can be believed that the lipid profiles were maybe regulated via estrogen.The AR extract has low effects on the lipid profiles at this dose and duration of treatment. The capacity of the extracts to decrease the MDA level and increase the SOD level in this study clearly reflected the antioxidant efficiency of these substances.

}, keywords = {Asparagus racemosus, Lipid profiles, Malondialdehyde, Ovariectomized rat, Superoxide dismutase}, doi = {10.5530/pj.2018.5.175}, author = {Ladachart Taepongsorat and Methin Phadungkit} }