@article {1350, title = {Evaluate the Effect of Herbal Extract Remedy for Treatment of Liver Cirrhosis in in-vitro}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {January 2021}, pages = {189-195}, type = {Research Article}, chapter = {189}, abstract = {

Objectives: To evaluate the in-vitro effect of herbal extract recepies, namely XGTQ, in the treatment of liver cirrhosis that induced by Carbon tetrachloride (CCL4) in combination with alcohol and high-fat diet in rats. Materials and Methods: Liver cirrhosis was induced by subcutaneously injecting CC14 (initial dose of 5,0ml/kg, followed by 1,2ml/kg twice a week in 10 weeks) in winstar rats. Then, fed with synthetic food, added 20\% fat, and 0.05\% cholesterol and iron oxalate. Rats were administered a day with fresh water and water mixed with 30\% ethanol in another day. The rats were randomly divided into 5 groups and given distilled water (group 1 or control group and group 2 or cirrhosis group), silymarin (group 3 or reference group) or the herbal recipes, aka XGTQ, drug extract (group 4, 5) for 4 weeks. Blood was collected for biochemical test and livers were dissected to evaluate weight, morphology and quantified 4-hydroxyproline to evaluate fibrosis and collagen accumulation. Results: In cirrhotic wistar rats, the XGTQ herbal drug at 19.6 g/kg/24h and 58.8 g/kg/24h showed the ability of reducing the level of enzymes AST, ALT in the blood (p\<0.01), increasing plasma albumin and decreasing prothrobin time (p\<0.05); improving physical condition, macroscopic and microscopic images of H\&E-stained liver; decreasing the concentration of hydroxyproline in the liver and reducing the level of cirrhosis on the masson-stained templates. The effect of herbal recipes XGTQ increased dramatically with the dose, and was equivalent to silymarin at the dose of 70 mg/kg/24h. Conclusion: The aqueous extract of XGTQ herbal remedy has have a good effect in treatment of liver cirrhosis in in-vitro and to be equivalent to that of silymarin at the dose of 70 mg/kg.

}, keywords = {CCl4, Liver cirrhosis, Silymarin, Wistar Rats, XGTQ herbal extract}, doi = {10.5530/pj.2021.13.27}, author = {Thanh Ha Tuan Nguyen and Ngan Nguyen Hoang and Xuan Thanh Nguyen and Binh Nhu Do and Son Trinh The} } @article {233, title = {In-vivo Hepatoprotective Activity of Methanolic Extracts of Sphaeranthus amaranthoides and Oldenlandia umbellate}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {November 2016}, pages = {98-101}, type = {Original Article}, chapter = {98}, abstract = {
Objective: The present study was carried out to evaluate the in vitro hepatoprotective activity of unexploited plants, Sphaeranthus amaranthoides and Oldenlandia umbellate\ on CCl4 induced liver injury, which are indigenous to South India. Methods: in the present study the methanolic extracts from Sphaeranthus amaranthoides and Oldenlandia umbellata were studied against the carbon tetrachloride hepatotoxicity. Results: significant hepatoprotective effect was obtained against carbon tetrachloride induced liver damage as judged from serum marker enzyme activities (SGOT, SGPT, ALT, and TB) and a normal architecture of liver compare to toxic control. Conclusion: the result revealed that methanolic extracts of Sphaeranthus amaranthoides and Oldenlandia umbellata could be useful in preventing CCl4 induced liver injury.
}, keywords = {ALP, CCl4, Hepatoprotective activity, Oldenlandia umbellata, SGOT, SGPT, Sphaeranthus amaranthoides, TB.}, doi = {10.5530/pj.2017.1.16}, author = {Somnath De and Ramalingam Suresh and Akula Murali Sri Sudhakar Babu and Siddabathuni Aneela} } @article {78, title = {Hepatoprotective effect of Livplus-A polyherbal formulation}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {01/2015}, pages = {311-316}, type = {Original Article}, chapter = {311}, abstract = {

Objective: The aim of the present study was to investigate the hepatoprotective effect of Livplus (a polyherbal formulation) against CCl4-induced hepatotoxicity in rats. Methods: Hepatotoxicity was induced in rats by i.p. injection of CCl4 once three days for 14 days. Livplus or Silymarin was administered along with CCl4 and the biochemical parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkalinephosphatase (ALP), total bilirubin (TB), direct bilirubin, total protein (TP), gamma-glutamyl transferase (GGT), total cholesterol (TC) and triglycerides (TG) were estimated. Furthermore, biomarkers of oxidative stress such as MDA levels, Glutathione contents, SOD and catalase activity in liver tissue were estimated. Results: Treatment with Livplus significantly reduced the elevated levels of ALT, AST, ALP, bilirubin (direct and total), GGT, TC, TG and increased levels of TP compared to CCl4 control rats. The treatment with Livplus also showed a significant increase in glutathione contents, SOD and catalase activity and a decrease in MDA levels compared to CCl4 control rats. Conclusion: The finding of present study indicates that Livplus showed a potential hepatoprotective activity. These results support the traditional use of Livplus in the treatment of liver disorders.

}, keywords = {CCl4, GGT, Hepatic enzymes., Hepatotoxicity, Livplus}, doi = {10.5530/pj.2015.5.11}, author = {Rajesh Maheshwari and Bhagyashree Pandya and Ramachandran Balaraman and Avinash Kumar Seth and Yogesh Chand Yadav and Vasa Siva Sankar} }