@article {811, title = {The Anti-Angiogenic Properties of Morinda citrifolia. L (Mengkudu) Leaves Using Chicken Chorioallantoic Membrane (CAM) Assay}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {January 2019}, pages = {12-15}, type = {Original Article}, chapter = {12}, abstract = {

Background: Anti-angiogenesis or inhibition of blood vessel formation is the best way to prevent the growth and metastasis of tumors. The use Morinda citrifolis. L extracts have been reported to exhibit a broad range of therapeutic effects, including antibacterial and antitumor. Objective: This study aims to investigate the anti-angiogenic properties of Morinda citrifolia. L leaves extracts using Chicken Chorioallantoic Membrane (CAM) assay. Materials and Methods: The Fertile White Leghorn eggs were divided into five groups which were control, Bevacizumab drug and treatment groups with 25\%, 50\% and 75\% of Morinda citrifolia. L leaves extracts respectively. The reduction of the blood vessel was counted after 12 h and 24 h post-treatment. Results: Analysis have shown significant differences (P\<0.05) in the reduction of the blood vessel between each group at 24 h post-treatment. The group with 75\% extracts showed 37.1\% reductions of blood vessel compared to groups 50\% and 25\% extracts which showed 4\% and 12.8\% respectively. The phytochemical screening has showed that Morinda citrifolia. L leaves extracts was positive for flavonoid, phenols and phytosterols. Conclusion: Morinda citrifolia. L leaves extracts consist of the phytochemical compounds that have the ability to inhibit the angiogenesis.

}, keywords = {Anti-angiogenesis, Chicken Chorioallantoic Membrane (CAM) assay, Morinda citrifolia. L leaves, Phytochemical, White Leghorn eggs}, doi = {10.5530/pj.2019.1.3}, author = {Zulhabri Othman and Hamimi Rasyiqah Hassan Khalep and Azrina Zainal Abidin and Halijah Hassan and Santosh Fattepur} }