@article {941, title = {Evaluation of Anti-diarrheal and Anti-nociceptive Activity of Methanolic Unripe Fruit Peels Extract of Masua ferrea Linn. on Mice Models}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {July 2019}, pages = {828-835}, type = {Original Article}, chapter = {828}, abstract = {

Background: Though traditionally the plant Masua ferrea has been used by south east Asian people in inflammation and septic conditions, the present study was designed to investigate the anti-diarrheal and anti-nociceptive activities of unripe fruit peel of Mesua ferrea on animal models. Methods: Various methods were employed for investigating these activities such as castor-oil induced diarrhea, castor-oil induced enteropooling and gastrointestinal motility test, acetic acid induced writhing test, tail immersion and hot plate methods. Results: From the experimental data it was found that the diarrheal episode was inhibited by 39.68\% and 49.21\% for methanol extract at the doses of 100 and 200 mg/kg respectively. The extract significantly lessened the intestinal volume for methanolic extract at 200 mg/Kg dose 0.54 {\textpm} 0.01 ml (p \< 0.05) and at 200 mg/Kg dose 0.47 {\textpm} 0.02 ml (p \< 0.01) compared to control 0.65 {\textpm} 0.03 ml in castor-oil induced enteropooling and also decreased intestinal transit 29.07 {\textendash} 48.54\% for methanolic extract comparable with standard (loperamide 5 mg/kg). Mesua ferrea peels significantly (P \< 0.05, P \< 0.01 and P \< 0.001) reduced the number of writhing, increased latency to flick tail in tail immersion method and elevated the mean basal reaction time in hot plate method respectively. Besides, no delayed toxicity was observed in given doses. Conclusion: The methanolic extract exhibited highly significant anti-diarrheal and antinociceptive activity in a dose-dependent manner, which supports its use in traditional herbal medicine.

}, keywords = {Anti-diarrheal, Anti-nociceptive, Castor oil, Intestinal transit, Mesua ferrea, Tail immersion method}, doi = {10.5530/pj.2019.11.133}, author = {Kishor Mazumder and Ziku Chandra Dey and Suparna Dey and Md. Fazlul Kabir and Minhazur Rahman and Sadiur Rahman Sajon} } @article {818, title = {Investigation on Pharmacognostic Parameters of Sirunagapoo (Mesua ferrea L): A Traditional Indian Herbal Drug}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {February 2019}, pages = {225-230}, type = {Research Article}, chapter = {225}, abstract = {

Introduction: Flower buds of Sirunagapoo (Mesua ferrea) are used in Siddha system of medicine as carminative, astringent and anti-vatha. It is traditionally used to treat various diseases like cough, venerial, white discharge, diarrhea, over-bleeding and peripheral neuritis. It is one of the major ingredients in Amukkara choornam, Inji choornam and Elathi choornam which are used for indigestion, loss of appetite and gastritis. Methods: Pharmacognostic characters of M. ferrea flower bud were studied through powder microscopy. Both ethanol and aqueous extracts were investigated for phytochemical screening, total phenolic content, in vitro antioxidant and anti-inflammatory properties and the ethanolic extract was subjected to GC-MS analysis. Results: Powder microscopy of flower buds of M. ferrea revealed the presence of brachysclereids, macrosclereids, starch grain, crystals and parenchyma cells. The powdered material exhibited 6.07\% of loss on drying, 2.93\% of total ash, 11.34\% of water-soluble extractive and pH value 5.35. Data showed the presence of sterols only in ethanol extract and phenols, flavanoids, saponins and coumarins in both ethanol and aqueous extracts. Ethanolic extract was found to contain higher concentration of total phenols (1030 mg GAE/L) when compared to aqueous extract. Totally forty compounds were detected in GC-MS analysis and the major compound is eugenol (61\%) and cinnamaldehyde (15\%). In vitro studies revealed antioxidant in terms of DPPH free radical scavenging property (IC-50 = 229.7 mg/ml) remarkable anti-inflammatory activity using RBC membrane stabilization assay (70.27\%) were noted. Conclusion: This study provides the pharmacognostic standards, phytochemical profile, major volatile compounds and in vitro properties of Mesua ferrea flower bud.

}, keywords = {GC-MS, In vitro studies, Mesua ferrea, Pharmacognosy, Phytochemicals}, doi = {10.5530/pj.2019.11.35}, author = {Perumal Rajalakshmi and Vellingiri Vadivel and Natesan Ravichandran and Pemaiah Brindha} }