@article {1222, title = {Identification of the Chemical Compound of Essential Oil from Ketumbar (Coriandrum sativum L.) Leaves with Gc-Ms}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {August 2020}, pages = {1019-1023}, type = {Original Article}, chapter = {1019}, abstract = {

Introduction: Coriandrum sativum L. leaves are plants used as a cooking spice that has a distinctive aroma. Various components of bioactive compounds are known from various parts of this plant, but the components of the bioactive compounds of essential oils from the leaves have never been reported. Objective: This research was designed to analyze the components of bioactive compounds contained in the essential oil of C. sativum leaves using a modified simple distillation tool. Method: C. sativum leaves essential oil component analysis with GC-MS (Shimadzu QP-2010 Plus). Results: Analysis GC-MS of the content of the bioactive compounds of essential oils contained various bioactive compounds. The dominant bioactive compounds are 2-Decen-1-ol (17.01\%), 9-Octadecenal (9.59\%), 1-Decanol (8.20\%), Dotriacontane (4.40\%), and Tetrapentacosan (3.68\%). Conclusion: The results of the research showed that there were various bioactive compound contents from the essential oil of C. sativum leaves and it was important to test the activity of each component of the bioactive compound as an important recommendation for pharmaceutical natural ingredients.

}, keywords = {Bioactive compounds, Coriandrum sativum, Distillation, Essential oil and GC-MS}, doi = {10.5530/pj.2020.12.144}, author = {Kasta Gurning and Iksen and Helen Anjelina Simanjuntak and Hermawan Purba} } @article {861, title = {Antithrombotic Effect of Mucuna pruriens L. and Coriandrum sativum}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {February 2019}, pages = {413-417}, type = {Original Article}, chapter = {213}, abstract = {

Background: Mucuna pruriens (MP) L. and Coriandrum sativum (CS) have been found for in vitro antithrombotic activity. However, the in vivo studies for both plants have not been discovered yet. Objective: The objective of the study is to prove the efficacy of MP L. and CS by conducting in vivo antithrombotic activity test with bleeding time and survival rate as the parameters. Materials and Methods: MP and CS extracts with three different doses were given orally to the experimental animals for 7 days. Aspirin was used as a positive control. The bleeding time was observed on mice tail that had been cut, and the survival rate was determined by inducing thrombosis with collagen{\textendash}epinephrine injection. Results: Seven-day treatment of plant extracts significantly prolonged the bleeding time of the treated group compared to the normal control group. The result demonstrated the increasing number of survived animals in the treated group compared to the negative control group. Conclusion: Both extracts had shown antithrombotic activity by significantly prolonged the bleeding time and increased the survival rate.

}, keywords = {Antithrombotic, Bleeding time, collagen, Coriandrum sativum, Mucuna pruriens L, Survival rate}, doi = {10.5530/pj.2019.11.64}, author = {Nuriza Ulul Azmi and Astari Rachma Nityasa and Fadlina Chany Saputri} } @article {1012, title = {The Effect of Coriander Ethanol Extract (Coriandrum sativum L.) Against Phagocytosis Activity and Capacity of the Macrophage Cells and the Percentage of Leukocyte Cells in White Male Mice}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {October 2019}, pages = {1290-1298}, type = {Original Article}, chapter = {1290}, abstract = {

Coriander has long been used by humans as a traditional drug and to enhances the taste of foods. This study aims to know the effects of coriander ethanol extract against phagocytosis activity and capacity of the macrophage cells and the percentage of leukocytes. The test animals used were white male mice which divided into 4 groups and each group consists of 5 mice. The first group (control) was given with 0.5\% Na CMC suspension. The second, the third, and the fourth groups were given with coriander extract each with doses of 100 mg/kg, 140 mg/kg and 200 mg/kg orally for 7 days long. On the 8th day, the mice were induced by Staphylococcus aureus to help their immune system. The results showed that the administration of coriander extract at doses of 100, 140 and 200 mg/kg can increase the phagocytic activity of macrophages by 44.6\%; 54.2\%; and 60.2\% each, while the phagocytic capacity replaces the results of 95.8; 104.4; and 126 cells. The total number of leukocytes showed were 5210, 6190, and 7310 /μL blood. In the number of leukocyte cells, the amount of coriander extract can reduce the number of neutrophil and monocyte cell segments. The conclusion of this study regarding coriander ethanol extract at doses of 100, 140 and 200 mg/kg can increase phagocytosis activity and capacity of the macrophage cells and the total leukocyte cell counts in male white mice.

}, keywords = {Activity, Coriandrum sativum, Leukocytes, Macrophages, Phagocytosis capacity}, doi = {10.5530/pj.2019.11.200}, author = {Dwisari Dillasamola and Yufri Aldi and Marselani Kolobinti} }