@article {1425, title = {Evaluation of Antioxidant and Anticancer Activity of Myristica fragrans Houtt. Bark}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {May 2021}, pages = {780-786}, type = {Research Article}, chapter = {780}, abstract = {

This study aims to evaluate the antioxidant and anticancer activity of secondary metabolite compounds from Myristica fragrans Houtt. (nutmeg) bark using n-hexane extract based on DPPH radical scavenging and microculture tetrazolium salt (MTT) assay. The chemical structural analysis using NMR, FTIR, and LC-MS spectroscopy confirmed and identified the structure of isolated compound namely (2E)-5(2z.4E)-hexa-2,4,-dio-zyl)-2propylcyclohexanol (C18H30O4) for the first time which is corresponding for the excellent antioxidant and anticancer activity against MCF-7 cell lines with the IC50 value of 99.76 and 10.75 ppm, respectively.

}, keywords = {Anticancer, Antioxidant, Bark, n-hexane extract, Nutmeg (Myristica fragrans Houtt)}, doi = {10.5530/pj.2021.13.99}, author = {Binawati Ginting and Mustanir and Nurdin and Maulidna and Murniana and Safrina} } @article {1107, title = {Condensed Tannins Content and their Influence on the Antioxidant Activity of Bark Hydroethanol Extract of Piliostigma reticulatum (Dc) Hochst and its Fractions}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {March 2020}, pages = {361-368}, type = {Research Article}, chapter = {361}, abstract = {

Background: Consumption of natural products from plants is implicated in the reduction of the occurrence of diseases related to oxidative stress. Piliostigma reticulatum is a plant well known to traditional practitioners in Senegal where leaves and bark are often used against many diseases, such as ulcers, boils, syphilitic cancer, toothache, gingivitis and diarrhea. Aim: This study compared hydroethanol extract from the plant bark and its fractions by assessing their total phenol contents, antioxidant activity and the influence of condensed tannins on their activity. Method: barks were extracted by a moderate decoction with ethanol-water followed by a silica column fractionation with successively ethyl acetate, methanol and water. For this study, assays were carried out before and after precipitation of tannins by BSA and PVPP tests. Total phenol and condensed tannins of hydroethanolic extract and its fractions were performed by Folin Ciocalteu and hydrolysis methods. Antioxidant activity was evaluated by DPPH and CUPRAC tests. Results: Tannins precipitation leads a light decrease of total phenol and condensed tannins contents of samples. Total phenol content of hydroethanolic extract was 51.2 mg GAE/g vs 3.2 after BSA test and 1.7 after PVPP test whereas condensed tannins content obtained 72.2\% vs 4.2\% and 2.3\% after precipitation. Antiradical activity was lost following the elimination of tannins with IC50: 5.33 {\textpm} 0.04 mg/l vs 78.86 {\textpm} 0.92 after BSA and \> 500 after PVPP. Conclusion: This results showed the condensed tannins would be in charge of antiradical and reducing activities of plant barks and PVPP precipitated much better the tannins from those extracts than BSA.

}, keywords = {Antioxidant, Bark, Piliostigma reticulatum, Precipitation, Tannins}, doi = {10.5530/pj.2020.12.57}, author = {Serigne Ibra Mback{\'e} DIENG and C{\'e}line Mathieu and Abdou SARR and Kady Diatta-Badji and Alioune Dior FALL} } @article {974, title = {Comparative Evaluation of Anti-Inflammatory Potential of Ethanolic Extract of Leaf, Bark and Flower of Tecoma stans with Ibuprofen- An In vitro Analysis}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {September 2019}, pages = {1088-1092}, type = {Research Article}, chapter = {1088}, abstract = {

Background: Endodontics has always been indebted to pharmaceutical sciences to provide it with necessary analgesics and anti-inflammatory agents. More specifically, there has always been a need for anti-inflammatory phytotherapeutic agents as the commercially available synthetic anti inflammatory drugs have their own limitations due to undesirable side effects. Hence, novel potent analgesic and anti-inflammatory drugs without considerable side effects from the natural sources are under evaluation. Tecoma stans (Bignoniaceae) is an ornamental plant found throughout India. It has been shown to have variety of medicinal properties. In the present study, we have shown that potential anti inflammatory activity of different parts of Tecoma stans (T.stants) and compared with standard drug. Aim: To evaluate the in vitro anti inflammatory potential of different parts of T.stans ethanolic extract and to compare the anti inflammatory activity with standard drug ibuprofen. Methodology: The ethanolic extraction of T.stans{\textquoteright}s bark, leaves and floweres was done as per the standard method. Different concentrations (100, 200, 300, 400 and 500 μg/ml) of the extracts were used for anti-inflammatory activity by inhibition of albumin denaturation. All samples were analyzed in triplicate. The results were statistically analyzed. Results: All the three parts of the plant extract have shown to have anti inflammatory activity in a dose-dependent manner. However, the leaf and flower extracts of T.stans were found to have 100 percent anti-inflammatory pontential than standard drug ibuprofen. Conclusion: It is concluded from the present findings that T.stants possess anti-inflammatory properties which could be due to presence of active constitutents presen in the plant extracts. Hence, T.stans may serve as one of the anti inflammatory herbal durgs for Endontic infection-induced inflammation and related to dental diseases. Further studies on the identification of the active principles present in the leaf and flower extract are warranted to assertatin its potentials.

}, keywords = {Anti-inflammatory Effect, Bark, Flower, Leaf, Tecoma stans}, doi = {10.5530/pj.2019.11.170}, author = {Swarna SK and Nivedhitha MS and Vishnu Priya V and Gayathri R and Selvaraj J and Madhan K and Shyamala Devi B} }