@article {1843, title = {Triterpenoids from Agathis robusta Aerial Parts and Their Hepatopotective Activity}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {August 2022}, pages = {362-366}, type = {Research Article }, chapter = {362}, abstract = {

Objective: While Agathis robusta contains important phytochemical constituents and has been linked to a variety of biological activities, there is currently insufficient research on the plant{\textquoteright}s total phytochemical constituents or pharmacological activity. Materials and Procedures: The aerial part of Agathis robusta was extracted with 70\% methanol and was screened for new phytochemical components. The structures of the isolated compounds were elucidated by spectroscopic data interpretation. The hepatoprotective activity of the isolated compounds was investigated. Results: Four known triterpenoids and two new compounds were isolated for the first time from the methanolic extract of the aerial parts of A. robusta. Conclusion: For the first time, new triterpenoidal saponins with high hepatoprotective activity have been isolated from the aerial portion of A. robusta. As a result, it is suggested that more emphasis be placed on this plant{\textquoteright}s biological behavior.

}, keywords = {Agathis robusta, Hepatoprotective activity., Triterpenoid saponins}, doi = {10.5530/pj.2022.14.108}, author = {Amal H. Ahmed and Shaza A. Mohamed} } @article {1030, title = {Two Triterpenoid Saponins with alpha-glucosidase Inhibitory Activity from Harpullia pendula Seed Extract}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {November 2019}, pages = {1386-1390}, type = {Original Article}, chapter = {1386}, abstract = {

Background: Harpullia pendula Planch (family Sapindaceae) is a small to medium rainforest tree native to Australia. Objective: This study aims to isolate triterpenoid saponins from H. pendula and test them as α-glucosidase inhibitors. Materials and Methods: The saponin compounds were obtained using variable chromatographic techniques and characterized by spectral analysis. Results: Two new triterpenoid saponins were obtained as an inseparable mixture from H. pendula methanolic seed extract. Their structures were determined as 3-O-β-D-glucopyranosyl-(1{\textrightarrow}2)-[α-L-arabinofuranosyl-(1{\textrightarrow}3)]-βD-glucuronopyranosyl22-OangeloylA1- barrigenol and 3-O-β-D-galactopyranosyl-(1{\textrightarrow}2)-[α-L-arabinofuranosyl-(1{\textrightarrow}3)]-β-Dglucuronopyranosyl 22-O-(2-methylbutyroyl)-A1 barrigenol, respectively. The triterpene part 22-O-(2-methyl butyroyl) A1-barrigenol has never been characterized before. The α- glucosidase inhibitory activity of the two saponin mixture was evaluated invitro and proved to exhibit strong activity with IC50 value equals to 13.3 {\textpm} 5.0 ppm and IC90 value equals to 21.5 {\textpm} 8.0 ppm. Conclusion: Two new saponins were characterized from their mixture and found to exhibit α-glucosidase inhibitory activity.

}, keywords = {Harpullia pendula, Sapindaceae, Triterpenoid saponins}, doi = {10.5530/pj.2019.11.214}, author = {Marian Nabil and Neveen S Ghaly and Iman AA Kassem and Mary H Grace and Farouk R Melek} }