@article {1624, title = {Isolation and Structural Characterization of Compounds from Blumea lacera}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {July 2021}, pages = {999-1004}, type = {Research Article}, chapter = {999}, abstract = {

Background: The medicinal plants consider as a rich resource of ingredients which can be used in drug development and synthesis. Blumea lacera (Burm. f.) DC. is generally used in traditional medicine for the treatment of cough, bronchitis, dysentery, wound healing. The aim of this study is to isolate and identify the compounds from the aerial parts of Blumea lacera. Methods: The aerial parts of B. lacera were dried, powdered and extracted using EtOH, and the concentrated extract was partitioned in succession with n-hexane, CH2Cl2, and EtOAc. From the EtOAc fraction, the compounds were isolated through column chromatography and their chemical structures were elucidated by NMR spectroscopy and confirmed by comparison of their NMR data with literature data. Results: Repeated column chromatography of the EtOAc-soluble fraction from the aerial parts of B. lacera resulted in the isolation of β-sitosterol (1), campesterol (2), artemetin (3) and acid paracatechuic (4).

}, keywords = {Asteraceae, Blumea lacera, Column chromatography, Flavonoid}, doi = {10.5530/pj.2021.13.129}, author = {Xuan Phong Pham and Tran Thi Tuyet Nhung and Hoai Nam Trinh and Do Minh Trung and Dang Truong Giang and Binh Duong Vu and Nguyen Trọng Diep and Nguyen Van Long and Van Thu Nguyen and Chu Van Men} } @article {1428, title = {A Review of the Traditional Uses, Medicinal Properties and Phytochemistry of Centaurea benedicta L.}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {May 2021}, pages = {798-812}, type = {Review Article}, chapter = {798}, abstract = {

Centaurea benedicta L. is an annual herbaceous plant which belongs to the Asteraceae family. It is native to the Mediterranean region and western Asia and is commonly known as blessed thistle, holy thistle, St Benedict{\textquoteright}s thistle or spotted thistle. Traditionally, it has been used to treat bubonic plague and possesses diuretic, galactagogue, liver-strengthening and wound healing properties. Recent research studies have investigated its anticancer, antiinflammatory, antioxidant and other therapeutic properties. Several studies have also reported its antimicrobial activity against a range of bacterial pathogens. However, most of these studies were preliminary and only tested relatively high concentrations of the extracts. Additionally, most studies screened a limited number of pathogens. Cnicin is the main chemical compound present in C. benedicta and it has been widely investigated. However, few other compounds from this plant have been identified and/or investigated, and further phytochemical studies are warranted. Interestingly, pure cnicin has good anticancer activity, whilst the crude extracts lack cytotoxic properties. Phytochemical analyses of C. benedicta extracts reveal the presence of multiple flavonoids, tannins, terpenoids and lactones, although few specific phytochemicals within these phytochemical classes have been identified. A limited number of research studies have determined the toxicity profile of C. benedicta in order to evaluate its safety for human use. Substantially more detailed studies are required to rigorously investigate the therapeutic properties and phytochemistry of C. benedicta, which may ultimately lead to the development of new plant-based therapeutic medicines.

}, keywords = {Asteraceae, Blessed thistle, Flavonoids, St Benedict{\textquoteright}s thistle, Tannins, Terpenoids}, doi = {10.5530/pj.2021.13.102}, author = {Gagan Tiwana and Jiahe Fua and Lanping Lu and Matthew J Cheesman and IE.Cock} } @article {1662, title = {Synergistic Efficacy of Phytochemical, Antioxidant and Bactericidal Properties of the Aerial Essential Oil of Laggera crispata}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {September 2021}, pages = {1304-1311}, type = {Research Article}, chapter = {1304}, abstract = {

This study was undertaken to provide more scientific information about the phytochemical composition of Laggera crispata known for its medicinal uses. Essential oil was isolated by hydro-distillation, analysed using GC-MS, UV-Visible Spectrophotometer and other established biochemical assays were used for the study. The GC-MS analysis of the aerial essential oil of L. crispata showed the presence of 35 medicinal organic compounds making up 84.4\% of the oil. The most abundant component was a phenolic compound called 2-tert-Butyl-1,4-dimethoxybenzene (54.5\%). The other major terpenoids present in the oil were α-humulene (6.9\%) and (+)-sabinene (5.9\%). The TPC, TFC, TAA and TAC values of the aerial essential oil of L. crispata were 172.75{\textpm}0.00 μgmg-1 GAE, 48.69{\textpm}0.00 μgmg-1 QE, 61.85{\textpm}0.00 μgmg-1 AAE and 726.92{\textpm}0.00 μgmg-1 AAE respectively. DPPH IC50 and AAI values of the essential oil were 1.5 μgml-1 and 26.7. The essential oil displayed varying inhibitory activities against Gram-positive and Gram-negative bacteria with zones of inhibition ranging from 08-30 mm. The in vitro pharmacological activities added scientific support to the use of L. crispata in alternative and complementary medicine. The essential oil of L. crispata grown in Nigeria will play beneficial roles in human and animal health and therefore a research on this plant might be of great value in drug industries.

}, keywords = {Aerial essential oil, Antibacterial, Antioxidant, Asteraceae, Laggera crispata, Secondary metabolites}, doi = {10.5530/pj.2021.13.165}, author = {Ololade Zacchaeus S and Anuoluwa Iyadunni A and Adeyemi Adewale F and Uyaboerigha Daubotei I} } @article {104, title = {Seed oil chemical composition of Platychaeteaucheri (Boiss.) Boiss}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {09/2015}, pages = {42-43}, type = {Original Article}, chapter = {42}, abstract = {

Background: Platychaete aucheri is an endemic plant to the south of Iran and no phyochemical investigations is reported on the seeds oil. Materials and Methods: The chemical composition of Platychaete aucheri seeds oil was extracted by suxhelet apparatus, methyl esterificated and analyzed by GC and GC/MS spectroscopy method. Results: 16 compounds were determined in total and taraxasterol (19.0\%), \γ-sitosterol (14.1\%) and lupeol (11.8\%) were characterized as the most abundant components. Conclusion: Regarding the presence of high amounts of triterpenoids and sterols in the seed oil, related biological activities are expected from the studied oil.

}, keywords = {Asteraceae, gamma-Sitosterol., Platychaete aucheri, Seed oil, Taraxasterol}, doi = {10.5530/pj.2016.1.9}, author = {Jinous Asgarpanah and Narges Dakhili and Fatemeh Mirzaee and Maedeh Salehi and Maryam Janipour and Elaheh Rangriz} } @article {1522, title = {Isolation and identification of endophytic fungi in the medicinal plant Mikania laevigata (Asteraceae)}, journal = {Pharmacognosy Journal}, volume = {6}, year = {2014}, month = {26th May 2014}, pages = {10-15}, type = {Research Article}, abstract = {

The Mikania laevigata (Asteraceae) is a Brazilian medicinal plant used to treat respiratory tract diseases.It is produced on a large scale for phytotherapic formulation. No studies on the endophytes of Mikania laevigata have been described in the literature. The endophytic fungi isolated from the leaves of M. laevigata cultivated in a floral garden located in the south region of the Bahia state, Brazil, were investigated. After surface disinfection, the performing the isolation procedure, a total of forty endophytic fungi were obtained and grouped into different morphospecies. The fungi were characterized by molecular sequencing the ITS rDNA regions, and they were identified by comparing the results published Gen Bank sequences.The phylogenetic analyses revealed four major clades of fungi from the sequenced ITS-rDNA regions: Nodulisporium sp. (3 isolates), Hypoxylon sp.(3 isolates), Daldinia sp. (1isolate) and Xylaria luteo stromata (aunique isolate).The Xylariaceae Genus was the dominant group of fungi associated with Mikania laevigata.

Key words:Mikania laevigata, Asteraceae, Xylariaceae, Endophytic fungi.

}, keywords = {Asteraceae, Endophytic fungi, Mikania laevigata, Xylariaceae}, author = {Fernanda P.C. Ribeiro and H{\'e}lio M Kamida and Paulo R.M. Almeida and Ana P.T. Uetanabaro and Larissa C.B. Costa and Alexsandro Branco} }