@article {1158, title = {Lathraea squamaria L. (Orobanchaceae): A Review of its Botany, Phytochemistry, Traditional Uses and Pharmacology}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {May 2020}, pages = {667-673 }, type = {Review Article}, chapter = {667}, abstract = {

This paper presents the results of the review pharmacognostic study of common toothwort, a perennial plant, parasitizing on the roots of trees. Currently, in Russian traditional medicine, there is considerable experience in the use of сommon toothwort (Lathraea squamaria L.) herb and roots as antitumoral, biligenic, infertility-treatment and diuretic drugs. The chemical composition of L. squamaria has not been quite well determined. Phenylethanoid glycosides (acteoside, isoacteoside), iridoid glycosides (aucubin, and aucuboside ester, 6{\textquoteright}-O-glucopyranosyl-aucubin, melampyroside, 6{\textquoteright}-O-glucopyranosyl melampyroside), simple sugars, fatty acids, organic acids, β-sitosterol were identified. Further study of L. squamaria raw materials is a very promising field including implementation in official medicine.

}, keywords = {Aucubin, Chemical compounds, Common toothwort, Iridoids, Lathraea squamaria, Orobanchaceae, Parasitic plants}, doi = {10.5530/pj.2020.12.98}, author = {Bokov DO and Barkalova VE and Suslikova MA and Sokhin DM and Kakhramanova SD and Rendyuk TD and Strelyaeva AV and Antsyshkina AM and Balobanova NP and Prostodusheva TV and Grikh VV and Krasnyuk II1 (junior) and Marakhova AI and Moiseev DV} } @article {1306, title = {UPLC-PDA-ESI-MS/MS Profiling of Clerodendrum inerme and Clerodendrum splendens and Significant Activity Against Mycobacterium tuberculosis}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {November 2020}, pages = {1518-1524}, type = {Original Article}, chapter = {1518}, abstract = {

Introduction: Antibiotic resistance is a major problem that is spreading and increasing while the development of new antibiotics is ceasing. As a result, some bacterial infections that were easily treated previously became untreatable. The antibacterial activity of Clerodendrum inerme and Clerodendrum splendens leaves were investigated against Mycobacterium tuberculosis, the widely known multi-drug resistant bacterium. UPLC-PDA-ESI-MS/MS is characterized by high sensitivity, resolution and speed for identification of plant metabolites even the minor ones. The chemical constituents of the leaves of C. inerme and C. splendens were investigated by UPLC-PDA-ESI-MS/MS metabolic analysis. Methods: The antibacterial activity of the ethanol extracts of the leaves of the two species under investigation was evaluated against the multi-ethanol drug resistant bacterium Mycobacterium tuberculosis using MABA assay. The methanol extracts of the leaves of C. inerme and C. splendens were subjected to comparative UPLC-PDA-ESI-MS/MS analysis. Results: The ethanol extract of C .inerme leaves showed significant antibacterial activity against Mycobacterium tuberculosis, while that of C. splendens showed moderate activity. The UPLC-PDA-ESI-MS/MS analysis revealed a total of 36 metabolites detected and tentatively identified in the two species under investigation, among them 28 chromatographic peaks were assigned in C. inerme while only 14 were assigned in these C. splendens. The main classes of secondary metabolites detected were Phenylpropanoid and, iridoid glycosides, flavonoids, diterpenoids, phenolic acid and fatty acid derivatives. Conclusion: The results of the antibacterial activity and UPLC-PDA-ESI-MS/ MS analysis showed stronger activity and higher number of metabolites for C. inerme as compared to C. splendens.

}, keywords = {Clerodendrum, Diterpenoids, Iridoids, Mycobacterium, Phenyl-propanoids, UPLC profiling}, doi = {10.5530/pj.2020.12.208}, author = {Hesham I Elaskary and Omar M Sabry and Asmaa M Khalil and Soheir M El Zalabani} }