@article {2546, title = {A Review on Chemical Profile and Pharmacological Properties of Marine Sponge Tectitethya Crypta}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {September 2025}, pages = {608-619}, type = {Original Article}, chapter = {608}, abstract = {

Marine sponges have gained recognition as a valuable resource due to their significant pharmacological properties. The investigation of substances produced by sponges has been extensively researched to identify their pharmacological properties. Marine sponges, which are part of the phylum Porifera, are thought to be the main source of marine natural products. Sponges are multicellular organisms that have a number of pores and channels for exchanging water; the secondary metabolites they create are in turn influenced by their specific environmental circumstances. Natural products such as lipids, terpenoids, peptides, alkaloids, and steroids are abundant in the marine sponge genus Tectitethya crypta. These compounds have unique chemical structures and have shown promising biological activities, making them ideal candidates for the development of novel drugs to treat various ailments. Tectitethya crypta is a sessile filter-feeder that produces a variety of bioactive compounds, including nucleosides and other secondary metabolites. This article reviews the biology and chemistry of Tectitethya crypta and serves as an introduction to the organism. We discuss the taxonomic classification, morphology, and microenvironment of the sponge, as well as the chemical structures and biological activities of its bioactive compounds. Tectitethya crypta was the source for the development of vidarabine, ara-C, and gemcitabine, which are used to treat viruses and cancer, respectively. We discussed about how these molecules may be used to treat parasitic and infectious disorders.

}, keywords = {Anticancer drugs, Antiviral drugs, Bioactive compounds, Marine sponges, pharmacological properties}, doi = {10.5530/pj.2025.17.76}, author = {Durga Prasad Kondeti and T. Sundarrajan} } @article {1211, title = {Protective Effect of Natural Products against Chemotherapy-Induced Cardiotoxicity: A Review}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {August 2020}, pages = {1180-1189}, type = {Review Article}, chapter = {1180}, abstract = {

Background: Cancer is one of the diseases with high mortality rate recorded each year across the world. Its mainstay treatment is chemotherapy although they are largely toxic, causing severe adverse reactions including cardiotoxicity, nephrotoxicity and genotoxicity. Cardiotoxicity is unique to certain chemotherapeutic agents and occur via several mechanisms. It has been hypothesized that co-administration of natural products which may be cardioprotectant, together with chemotherapy can alleviate cardiotoxicity-induced by chemotherapy. Objectives: This review aimed to provide a brief information about the protective effect of natural products against chemotherapy-induced cardiotoxicity Methods: To complete this review, relevant literatures were searched from several scientific databases including Google, Google Scholar, Scopus, Web of Science and Pubmed. Results: In this paper, we have reviewed ten natural products (curcumin, mangiferin, naringenin, quercetin, 6-gingerol, lycopene, resveratrol, apigenin, proanthocyanidins and indole-3-carbinol), which have major influences in attenuating chemotherapy-drug induced cardiotoxicity. Apart from the cardioprotective effects, they tend to confer some synergistic effects with chemotherapeutic agents and therefore have the potential to be used as an adjunct. Conclusion: Though a panel of natural products demonstrate protective effects against cardiotoxicity in cells and animal models, their therapeutic potentials for clinical needs further investigation.

}, keywords = {Anticancer drugs, Cardioprotective, Cardiotoxicity, Chemotherapy, Natural products}, doi = {10.5530/pj.2020.12.166}, author = {Siti Nurul Najiha Othman and Pei Teng Lum and Siew Hua Gan and Shankar Mani and Mahendran Sekar} }