@article {2205, title = {Unlocking the Potential of Stingray (Dasyatis sephen) Extract: A Novel Investigation into EPA and DHA Effects on Lipid Metabolism in High-Fat Diet-Fed Wistar Rats}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {February 2024}, pages = {28-36}, type = {Original Article}, chapter = {28}, abstract = {

Introduction: Dyslipidemia is a complex disturbance in lipid metabolism with notable implications for cardiovascular health. Considering the burden of cardiovascular disease (CVD) on global mortality, lipid regulation should be eminently prioritized. Stingray (Dasyatis sephen) is one of the natural resources believed to be rich in lipid-regulating compounds: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We aimed to investigate the impact of the stingray extract on the lipid metabolism of Wistar rats subjected to a high-fat diet. Methods: We adopted a true experimental design with three experiment groups: a negative control (standard diet and distilled water), a positive control (high-fat diet and distilled water), and a specified treatment group (high-fat diet and stingray extract). Serum samples were collected after 28 days of treatment and analyzed for HDL and ApoB levels as dyslipidemia markers. Statistical analysis included one-way ANOVA for HDL and non-parametric Kruskal-Wallis tests for ApoB levels, followed by post-hoc analysis. Results: The results revealed worsening HDL and ApoB levels in the positive control group compared to the negative control group following a high-fat diet consumption. In contrast, the experiment group showed improvements in HDL and ApoB levels compared to the positive control group following the administration of the extract. However, only the dynamics in HDL level are significant (p\<0.05), while the difference in ApoB levels among all treatment groups was not statistically significant (p\>0.05). Conclusion: This study highlights the potency of D. sephen extract in regulating lipid metabolism despite the complexity of lipid metabolism regulation and the challenges of the conventional reliance on HDL and ApoB as exclusive markers of cardiovascular health.

}, keywords = {ApoB, Dasyatis sephen, HDL, stingray}, doi = {10.5530/pj.2024.16.4}, author = {Sihning EJT and Ni Komang Sri Dewi Untari and Dian Maria Pia} } @article {1321, title = {Seagrass in the Control of Hyperglycemic and Hyperlipidemic States of Streptozotocin Induced Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {November 2020}, pages = {1716-1721}, type = {Research Article}, chapter = {1716}, abstract = {

Background: The present study intended to evaluate the beneficial effects of the seagrass Halophila beccarii, against induced diabetes mellitus in rat models. Halophila beccarii is a type of Seagrass abundant in Pulicat Lake of Andhra Pradesh, India. Objective: Evaluating the anti-hyperglycemic and anti-hyperlipidemic properties of seagrass extract in comparison with standards. Materials and Methods: STZ induced diabetic rat models were adopted to analyze the effect of long-term treatment with seagrass extract on blood glucose, HbA1c and serum lipids. Results: The methanolic extract of seagrass demonstrated a significant drop of blood glucose levels (52\%), in diabetic rats, after 6 h of supplementation. After 40 days of treatment with 500 mg/day of seagrass extract, STZ diabetic rats exhibited tremendous decrease in fasting blood glucose with significant improvement in glycemic control as evidenced by controlled levels of HbA1c. Lower levels of triglycerides, total cholesterol, LDL and VLDL cholesterols and higher levels of HDL cholesterol in STZ-induced diabetic rats provided an evidence for significant anti hyperlipidemic property of seagrass extract. Conclusion: Phytochemicals of seagrass like phenols, flavonoids and bioactive lipids contribute to the anti-hyperglycemic and anti-hyperlipidemic activities and Halophila beccarii extract serves as a natural supplement in the management of diabetes.

}, keywords = {Diabetes mellitus, FBG, Halophila beccarii, HbA1c, HDL, LDL}, doi = {10.5530/pj.2020.12.232}, author = {M Vani and P Uma Maheswari Devi} }