@article {2024, title = {Review on Phytochemistry of Medicinal Plants Documented for the Treatment of Low Sperm Count in Oluponna, Nigeria}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {April 2023}, pages = {439-446}, type = {Review Article}, chapter = {439}, abstract = {

According to the literature, approximately 32\% of adult males in developing countries suffer from infertility, however, majority of them use herbal remedies with reported benefits such as improved sperm quality, sexual functions, libido and testosterone levels. Recently, the World Health Organization emphasized the importance of documenting active medicinal plants used in various continents. Therefore, this present review focused on the phytochemistry of medicinal plants reported for the treatment of low sperm count in Oluponna area of Osun state, documented in an ancestral local record. Thirteen medicinal plants were documented to be used for management of low sperm count among men in this community. The plants listed in the document belong to ten families and 12 genera. The most cited family in this record is Apocynaceae with three species of plants namely, Alstonia boonei, Laidolphia dulcis, and Rauwolfia vomitoria respectively. Since this is the first review on the documentation of an ancestral knowledge and application of medicinal plants as means of passing the knowledge from a generation to another in Oluponna, additional toxicological and pharmacological studies are hereby recommended in order to provide scientific rationale for the long-term knowledge and use of these plants.

}, keywords = {Ancestral medicinal plants records, Drug development., Infertility, Low sperm count, Phytochemistry}, doi = {10.5530/pj.2023.15.69}, author = {Akingbolabo Daniel Ogunlakin and Oyindamola Esther Awosola and Gbenga Temidayo Ajayi and Oluwafemi Adeleke Ojo} } @article {1337, title = {The Effect of Giving Red-fleshed Watermelon Juice (Citrullus lanatus (Thunb.)) on Pregnant White Mice (Mus Musculus) Exposed by Monosodium Glutamate (MSG) Orally on the Number and Morphology of Fetus}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {January 2021}, pages = {97-102}, type = {Original Article}, chapter = {97}, abstract = {

Introduction: Infertility can occur due to the presence of free radicals. One of the most popular of free radical is monosodium glutamate. Free radicals from monosodium glutamate can be prevented by antioxidant compounds. Red-fleshed-fleshed watermelon is a fruit that contains antioxidant compound such as lycopene. Aim: This research was conducted to see the effect of red-fleshed-fleshed watermelon juice on the fetus including number, morphology, visual abnormalities and body weight of pregnant white mice exposed to monosodium glutamate solution orally. Total of 25 female white mice aged around 2-3 months were used as test animals. Methods: Pregnant white mice were divided into 5 test groups. Group I and II served as negative controls (whithout treatment) and positive controls (exposed to monosodium glutamate solution orally at dose of 1g/kgBW). Group III was given a solution of monosodium glutamate orally at dose of 1 g/KgBW added red-fleshed-fleshed watermelon juice at dose of 1.4 g/kgBW. Group IV was given solution of monosodium glutamate orally at dose of 1 g/KgBW added red-fleshed-fleshed watermelon juice at dose of 4.2 g/kgBW. The research data were processed using the one-way ANNOVA test. Results: The result showed that mice body weight, fetal number and morphology (body weight, body length, tail length, and head diameter) did not significantly influence (p\>0.05). However, it significantly affected the weight gain of mice during pregnancy. However, it significantly affected the weight gain of mice during pregnancy day 6 to day 17 of pregnancy (p\<0.05) and found abnormalities in the fetus such as low birth weight (LBW) and haemorrhage in group II and III. Conclusion: It can be concluded that watermelon juice at dose of 2.8 g/kgBW and 4.2 g/kgBW are effective in ward offfree radicals from monosodium glutamate orally at dose of 1 g/kgBW.

}, keywords = {Fetus, Infertility, Lycopene, Monosodium glutamate, Red-fleshed watermelon}, doi = {10.5530/pj.2021.13.14}, author = {Dwisari Dillasamola and Fitri Rachmaini and Dian Ayu Juwita and Rini Haryati} }