@article {2166, title = {Alteration of IL-6, BMP-15 and GDF-9 Levels on PCOS Rat Models After Treated with Syzygium Polyanthum (Wight) Walp Leaves Extract}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {December 2023}, pages = {1084-1090}, type = {Original Article}, chapter = {1084}, abstract = {

Background: Polycystic ovary syndrome (PCOS) is a global health concern for women in reproductive age women. Numerous studies have been reported an association between chronic inflammation and alteration of cytokine in women with PCOS. Syzygium polyanthum (S. polyanthum) contains antioxidants and has antiinflammation activity. Objectives: This study aims to measure the alteration of IL-6, BMP-15, and GDF-9 in rat PCOS model after treated with S. polyanthum leaves extract. Materials and Methods: The female Wistar rats were divided into five groups (n = 5), K0 (normal control), K1 (PCOS group), and three treatment groups which received three different doses of S. polyanthum leaves extract. The treatment group consisted of PCOS rat models with S. polyanthum leaves extract supplementation of 150 mg/KgBW (P1), 300 mg/KgBW (P2), and 450 mg/KgBW (P3). Results: IL-6 expression was highest in K1 (4,690 {\textpm} 0.099) and lowest in the P3 treatment, namely (2,370 {\textpm} 0.105). The expression of BMP-15 and GDF-9 was lowest at K1 (2.554 {\textpm} 0.04; 4.502 {\textpm} 0.050) and highest at P3, namely (2.265 {\textpm} 0.072; 4.736{\textpm}0.074). Conclusion: S. polyanthum leaves extract was significantly effective in decreasing IL-6 expressions, as well as a significant increase in BMP-15 and GDF-9 expressions in the PCOS rat model.

}, keywords = {BMP-15, GDF-9, IL-6, Syzygium polyanthum}, doi = {10.5530/pj.2023.15.198}, author = {Renny Aditya and Budi Santoso and Widjiati} } @article {1925, title = {Differences in interleukin-6 and interleukin-17 expression in covid-19 post-mortem lung tissue biopsy compared with noncovid- 19}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {January 2023}, pages = {887-892}, type = {Original Article }, chapter = {887}, abstract = {

Background: COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality. Objective: This study aims to determine the differences in the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients compared to non-COVID-19 patients. This study also aimed to analyze the correlation between the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients. Methods: This research is an observational analytic study with crosssectional approach. The samples were 15 paraffin blocks of post-mortem lung tissue biopsy of COVID-19 patients, and 15 paraffin blocks of inflammatory lung tissue biopsy or surgery of non-COVID-19 patients. IL-6 and IL-17 expressions were evaluated by immunohistochemical procedure. Result: There was a significant difference in the expression of IL-6 in the COVID-19 group and the non-COVID-19 group with a p-value = 0.001 (p \< 0.05). There was a significant difference in the expression of IL-17 in the COVID-19 group and the non-COVID-19 group with p-value = 0.001 (p \< 0.05). There was a significant correlation between the expressions of IL-6 and IL-17 in the COVID-19 group, with the Spearman coefficient value (rs) of 0.548 with p = 0.034 (p \< 0.05). Conclusion: There are differences in the expression of IL-6 and IL-17 between COVID-19 and non-COVID-19 lung tissue. There is a significant correlation between the expressions of IL-6 and IL-17 in post-mortem lung tissue of COVID-19 patients.

}, keywords = {Biopsy, COVID-19, IL-17, IL-6, Post mortem lung tissue.}, doi = {10.5530/pj.2022.14.184}, author = {Etty Hary Kusumastuti and Priangga Adi Wiratama and Grace Ariani and Stephanie Natasha Djuanda and Alphania Rahniayu and Nila Kurniasari and Dyah Fauziah and Anny Setijo Rahaju and Isnin Anang Marhana and Alfian Nur Rosyid and Dwi Wahyu and Gilang Muhammad Setyo Nugroho and Adhitri Anggoro and I Komang Rusgi Yandi and Bambang Pujo Semedi and Jilientasia Godrace Lilihata and Ummi Maimunah and Supriadi and Achmad Lefi and Lalu Galih Pratama Rinjani and Edi Suyanto and Ricardo Ardian Nugraha} } @article {1387, title = {Effect of Tender Coconut Water (TCW) on TNF-α, IL-1 and IL-6 in Streptozotocin (STZ) and Nicotinamid (NA) Induced Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {March 2021}, pages = {500-505}, type = {Research Article}, chapter = {500}, abstract = {

Background: Diabetes Mellitus (DM) is characterized by an increase in blood sugar levels also known as hyperglycemia. Continuous hyperglycemia can increase the production of Reactive Oxygen Species (ROS). ROS causes oxidative stress and increases the formation of TNF-α expression as a marker of inflammation. Tender coconut water is rich in sources of free amino acids, L-arginine and vitamin C which can prevent oxidative stress. Aim and Objectives: This research to investigate the effect of tender coconut water on TNF-α, IL-1 and IL-6 in Streptozotocin (STZ) and Nicotinamid (NA) induced diabetic rats. Material and Methods: Experimental research design using posttest control group design. Twenty four male wistar strain rats were used in this study were divided randomly into 4 groups, which are group K1 (control); K2 (DM type 2); K3 (DM type 2+ Glibenclamid 0,18mg/200grBW); K4 (DM type 2+ tender coconut water 8mL/200gr BW). Type 2 Diabetes Mellitus were induced using Streptozotocin (STZ) 65mg/kg body weight and Nicotinamid 230 mg/kg body weight. The administration of tender coconut water were given on day 3 after DM condition is reached, given daily for 4 weeks with dose of 8 mL/200 gr BW. Data on of TNF-α , IL-1 and IL-6 levels were analyzed by One Way Anova. Result: Average TNF-α level, IL-1 level and IL-6 level in Group 2 increased compared to Group 1 , in Group 3 it decreased compared to Group 2 as well as in Group 4 .The results of the analysis has the p values \<0.05. Conclusion: Administration of tender coconut water can be decreasing of TNF-α, IL-1 and IL-6 levels in wistar strain male rats with type 2 Diabetes Mellitus.

}, keywords = {Diabetes mellitus, IL-1, IL-6, Tender coconut water, TNF-α}, doi = {10.5530/pj.2021.13.63}, author = {Siti Thomas Zulaikhah and Joko Wahyuwibowo and Mochammad Navi Suharto and Bagus Haruno Enggartiasto and Mohammad Iqbal Raka Ortanto and Arrizki Azka Pratama} }