@article {2006, title = {Effect of Rosmarinus Officinalis Essential Oil On Anxiety, Depression, And Sleep Quality}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {April 2023}, pages = {343-349}, type = {Research Article}, chapter = {343}, abstract = {

Introduction: The objective of this investigation was to evaluate the effect of Rosmarinus officinalis essential oil on anxiety, depression, and sleep quality. Methods: The essential oils were extracted by hydro-distillation using a modified Clevenger-type apparatus and the chemical composition was performed by Gas chromatography with flame ionization detection (GC-FID) and Gas chromatography mass spectrometry (GC{\textendash}MS). Furthermore, a quasi-experimental study was conducted, where 81 participants were divided into two groups, comprising a waiting list control group and an experimental group treated with essential oils. Anxiety and depression indexes were evaluated using the Zung Self-Rating Anxiety Scale (SAS) and the Zung Self-Rating Depression Scale (SDS), and sleep quality was measured with the Pittsburgh Sleep Quality Inventory (PSQI). Results: Chemical analysis showed that 1,8 cineole (37.6\%), α-pinene (19.9\%), and linalool (15.8\%) were the main components. Anxiety, depression, and sleep quality scores showed a decrease in the post-test study phase compared to the pre-test in the experimental group (p\<0.05). A large size effect was found in the case of anxiety (d = 1.491; g= 1.490) with 1-β=0.996, while medium size effects were observed for depression (d = 0.581; g= 0.582) with 1-β=0.585; and sleep quality (d = 0.586; g = 0.588) with 1-β=0.638. Conclusion: Essential oils extracted from Rosmarinus officinalis are more effective in calming anxiety and show moderate changes in depression and sleep quality.

}, keywords = {Anxiety, Depression, Essential oils, Rosmarinus officinalis, Sleep quality}, doi = {10.5530/pj.2023.15.52}, author = {Paul Alan Arkin Alvarado-Garc{\'\i}a and Maril{\'u} Roxana Soto-V{\'a}squez and Luis Enrique Rosales-Cerquin and Santiago M. Benites and Taniht Lisseth Cubas-Romero and Demetrio Rafael Jara-Aguilar and Jos{\'e} Gilberto Gavidia-Valencia and Iris Melina Alfaro-Beltr{\'a}n} } @article {1651, title = {Chemical Composition and Protective Effect of Rosmarinus officinalis on Alcohol-Induced Serum Hepatic Changes and Liver Injury in Male Rats}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {September 2021}, pages = {1205-1215}, type = {Research Article}, chapter = {1205}, abstract = {

Background: Is a pleasant-smelling perennial shrub that grows in many parts of the world, Rosmarinus officinalis a well known valuable herbal medicine which is widely used in pharmaceuticals and traditional medicine as a digestive, tonic, astringent, diuretic, diaphoretic and useful for urinary ailments. Objective: The objective of this study has, on the one hand, focused on the changes in hepatotoxicity induced by the chronic administration of ethyl alcohol according to a biochemical and histological experimental approach and, on the other hand, on the chemical composition which was determined. As well as, the hepato-protective effect of the ethanolic extract of Rosmarinus officinalis (EER), whether to restore or not the harmful alterations due to ethylism was evaluated. Method: The study included twenty-four male Wistar albino rats which were divided into four groups. The rats received ethanolic extraction of Rosmarinus officinalis orally at a dose of 200 mg/kg. Hepatotoxicity was induced orally with a daily dose of 05 mL of 20\% alcoholic solution for 90 days. Results: The chemical characterization of the ethanolic extract of Rosmarinus officinalis (EER) by HPLC/UV shows the presence of polyphenolic compounds and numerous flavonoids, the main constituent of which is rosmarinic acid. It was noticed that the Ethanol caused an increase in liver function parameters (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride and cholesterol, total bilirubin) compared to the control and oxidative stress through a significant decrease in antioxidant liver enzymes Superoxidase dismutase (9.39 U/mg), glutathione peroxidase (12.89 U/mg) and catalase (25.39 U/mg) and increased malondialdehyde levels. The histological study showed significant lesions in the liver. Conclusion: The disturbances in liver function, antioxidant status and structural damage to the liver caused by ethanol have been restored by the administration of the ethanolic extract of Rosmarinus officinalis which strongly justifies its therapeutic effect.

}, keywords = {Ethylism, Hepatotoxicity, HPLC/UV, Liver stress oxidatives, Rosmarinus officinalis}, doi = {10.5530/pj.2021.13.154}, author = {Rima Farah AOUAD and Mokhtaria Yasmina BOUFADI and Djallal Eddine Houari ADLI and Faiza MOULAI-HACENE and Khaled KAHLOULA and Miloud SLIMANI} } @article {1418, title = {Nephro- and hepatoprotective effect of Rosmarinus officinalis against damage induced with antiTB drugs using a chronic model}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {May 2021}, pages = {722-729}, type = {Original Article}, chapter = {722}, abstract = {

Nephro- and hepatoprotector effect of MeOH extract from R. officinalis against the liver and kidney damage caused by the mixture of RIF:INH:PZA, using a chronic in vivo model are described. MeOH extract (EMRO) was prepared by maceration process and was administered by oral via during 91 days in male Balb/C mice with RIF:INH:PZA-induced renal/liver damage, using silymarin (SIL) as a positive control. EMRO (250 mg/kg) favoured body weight gain respect to the antiTB group, this gain was better than that shown by the SIL. The AST and ALT values of the group that received the EMRO extract and SIL were similar to that the control group and low compared to the group antiTB with liver damage. In addition, the GPx, CAT and POx values of the group treated with the EMRO were similar to that the control group. In the liver histological analysis, no significant alteration was observed; however, a severe nephritis was observed in anti-TB group (II) and this effect was less in groups III (antiTB/SIL) and IV (antiTB/EMRO). MeOH extract enhances body weight gain and primarily protects the kidney and liver from damage caused by the antiTB drug mixture when was administered for 91 days.

}, keywords = {Antitubercular drug, Hepatoprotection, Methanolic extract, Nephroprotective effect, Rosmarinus officinalis}, doi = {10.5530/pj.2021.13.92}, author = {Siordia-Reyes Georgina A and Cornejo-Garrido Jorge and Jim{\'e}nez-Arellanes M. Adelina} }