@article {1812, title = {Potential Roles of Purslane (Portulaca oleracea L.) as Antimetabolic Syndrome: A Review}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {June 2022}, pages = {710-714}, type = {Review Article}, chapter = {710}, abstract = {

The number of cases of obesity and type 2 diabetes mellitus (T2DM) is part of the metabolic syndrome case. Purslane (Portulaca oleracea L.) is a plant that has been clinically tested and has the potential to prevent and treat metabolic syndrome as well as pathogenic and pathophysiological activities that cause disease. The aim of this study is to discuss and conclude information regarding the activity and use of purslane (P. oleracea) as an antimetabolic. This review article is based on scientific publications found on Google Scholar and PubMed databases using the keywords of {\textquotedblleft}Portulaca obesity{\textquotedblright}, {\textquotedblleft}Portulaca overweight{\textquotedblright}, {\textquotedblleft}Portulaca dyslipidemia{\textquotedblright}, and {\textquotedblleft}Portulaca metabolic syndrome{\textquotedblright}. This plant acts on numerous pathways in the metabolic syndrome such as reduction of lipids, blood sugar, body weight and total cholesterol. Purslane (P. oleracea) can be used as a candidate for a new herbal plant as an anti-metabolic syndrome.

}, keywords = {Body weight, Insulin resistance, Metabolic syndrome, Obesity., Portulaca oleracea}, doi = {10.5530/pj.2022.14.90}, author = {Nur Sofiatul Aini and Arif Nur Muhammad Ansori and Viol Dhea Kharisma and Muhammad Farraz Syadzha and Muhammad Hermawan Widyananda and Ahmad Affan Ali Murtadlo and Rasyadan Taufiq Probojati and Md. Emdad Ullah and Sin War Naw and Vikash Jakhmola and Rahadian Zainul} } @article {1495, title = {Portulaca oleracea extract increases lecithin:cholesterol acyltransferase and paraoxonase 1 activities and enhances reverse cholesterol transport in streptozotocin-induced diabetic rat}, journal = {Pharmacognosy journal}, volume = {6}, year = {2014}, month = {8th April 2014}, pages = {1-9}, type = {Original Article}, abstract = {

Background: Plant extracts are generally assumed to be more acceptable and less hazardous than synthetic compounds and could be alternative antidiabetic treatments. Portula caoleracea has been used as one of the traditional edible and medicinal plant in Algeria to treat diabetes. The aim of the present study was to determine the effects of lyophilized aqueous extract of Portulaca oleracea on high-density lipoproteins composition, paraoxonase (PON1) and lecithin:cholesterol acyltransferase (LCAT) activities in streptozotocin-induced diabetic rat. Methods: Diabetes was induced intraperitonially by a single injection of streptozotocin (STZ) (60mg/kg bw). Twelve diabetic rats, weighing 263\±5g, were divided into two groups fed a casein diet supplemented or not with Portulaca oleracea extract (1g/kg bw), for 4 weeks. Results: At d28, in Portulaca oleracea treated vs untreated diabetic group, glycemia, serum total cholesterol (TC), triacylglycerols (TG) and phospholipids (PL) concentrations were decreased significantly (p\<0.05). The hypolipidemic effect induced by Portulaca oleracea extract was due to the reduction of total cholesterol (TC) in LDL-HDL1 (-51\%) and C-HDL3 (-21\%). Portulaca oleracea treatment improved PON1 and LCAT activities by 48\%. HDL3-UC (acyl group acceptor) and -PL (enzyme substrate) were diminished respectively by 47\% and 82\%, whereas HDL2-CE concentrations (product of LCAT reaction) were increased by 44\%. Moreover, HDL-C levels were found to be positively correlated with PON1 activity (r=0.96, p\<0.05). Serum, LDL-HDL1, HDL2 and HDL3 TBARS levels were respectively, 2.9-, 2.6-, 2.4- and 2.8-fold lower in Portulaca oleracea treated than untreated diabetic groups. Conclusion: These findings reflect the potential antihyperglycemic and hypolipidemic of Portulaca oleracea extract, in STZ-induced diabetic rat. Moreover, Portulaca oleracea extract restores PON1 and ameliorates the reverse cholesterol transport (RCT) by enhancing LCAT activity, therefore could prevent many diabetic complications by reducing dyslipidemia and oxidative damage.

Key words: Rats, Streptozotocin, Portulaca oleracea, Cholesterol, PON1, LCAT, apo A-I, lipoprotein peroxidation.

}, keywords = {apo A-I, Cholesterol, LCAT, lipoprotein peroxidation, PON1, Portulaca oleracea, Rats, Streptozotocin}, author = {Guenzet Akila, and Krouf Djamil, and Berzou Saadia} }