@article {1661, title = {Application of Ultrasound-Assisted Extraction on the Stem Bark of Rhinachantus Nasutus (L.) Kurz, Total Phenolic, and Its Potential as Antioxidant and Inhibitor of Alpha-Glucosidase Enzyme Activity}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {September 2021}, pages = {1297-1303}, type = {Research Article}, chapter = {1297}, abstract = {

Aims: This study aims to obtain a stem bark extract of Rhinachantus nasutus (L.) Kurz through the application of ultrasound-assisted extraction (UAE) and reveal: the total phenolic content in the extract; The extract{\textquoteright}s potential as an antioxidant with copper-reducing strength parameters, and its potential as an antidiabetic by inhibiting alpha-glucosidase activity. Results: The crude ethanol extract of R. nasutus stem bark obtained from the UAE process was 7.4896 g with a yield of 4.99\%. The high total phenolic content, namely 677.3343{\textpm}0.0007 mg GAE / g sample, the antioxidant activity test using the CUPRAC method gave an IC50 value of 18.43{\textpm}0.20 mg / L. In addition, the ethanol extract of stem bark has a high ability to inhibit the activity of the alpha-glucosidase enzyme with an IC50 value of 10.95{\textpm}0.28 mg / L. Conclusion: The ethanol extract of the stem bark of R. nasutus from UAE has the potential as a source of antioxidants and antidiabetic.

}, keywords = {Alpha-glucosidase enzyme, Antidiabetic, Antioxidant, Rhinachantus nasutus (L.) Kurz, Total phenolics content, Ultrasound-assisted extraction}, doi = {10.5530/pj.2021.13.164}, author = {Candra Irawan and Berna Elya and Muhammad Hanafi and Fadlina Chany Saputri} }