@article {1978, title = {Analysis of Royal Jelly Apis Cerana as Therapeutic Candidate in Cbavd Based on Bioinformatics Studies}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {March 2023}, pages = {175-182}, type = {Research Article}, chapter = {175}, abstract = {

Background: Apis cerana honey bee is a honey bee native to Asia that spreads from Afghanistan, China, and Japan to Indonesia. The productivity of Apis cerana honey bees can produce as much as 2-5 kg of honey per colony in a year. Royal jelly is the queen{\textquoteright}s nourishment, and it is produced by larvae, adult bees, young worker bees, and male bee larvae. CBAVD contributes to 1{\textendash}2\% of the 20{\textendash}25\% of males with subfertility. Aim: The objective of this study was to evaluate Royal Jelly Apis Cerana as a potential therapeutic candidate for CBAVD using a bioinformatics approach. Method: This research method consisted of converting nucleotides into amino acids, analyzing the three-dimensional structure of Apis Cerana Royal Jelly Protein, Ramachandran Plot Analysis, Analysis of Epitope and Allergen Proteins, and Analysis of Proteins that were antigens and toxins. Results: The research results were conducted on six three-dimensional Apis Cerana Royal Jelly bee protein structures and had very good validity based on the Ramachandran plot, GQME value, and QmeanDisCo value. In addition, this study also obtained the results of proteins that are epitope, antigenic, non-allergenic, and non-toxic. Conclusion: The findings of this study can be used as a basis for therapy against CBAVD.

}, keywords = {Apis Cerana, Bioinformatics, CBAVD, Public health., Therapeutic Candidates}, doi = {10.5530/pj.2023.15.26}, author = {Maslichah Mafruchati and Jonathan Makuwia} } @article {1998, title = {The Aqueous Leaf Extract of Moringa Oleifera had Immunomodulatory Effects on Sheep that had Been Infected by Fasciola Gigantica, Clostridium Novyi Naturally and Impact to Fasciola gigantica Non-Embryonated}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {April 2023}, pages = {304-309}, type = {Original Article }, chapter = {304}, abstract = {

M., which received a (C), was the study{\textquoteright}s main objective. The whole thing was eaten. a couple of quotes from (C. dispersed in a liquid. has antibacterial properties (E. elegans). It{\textquoteright}s necessary to remove the body. C. Eczema on the face is comparable to this. Sheep and novyi both had organic infections. novyi. Following different combinations of treatments, a heavy dose of treatment, and a light dose, fasciolitis manifested in all three groups of infected sheep. The treatment groups received an oral 150 mg/kg aqueous M. oleifera leaf extract every 48 hours for 21 days. Body mass, fecal egg counts, blood anti-Fasciola IgG levels, cytokines (IL-2, IL-17, and IL-10), and C. the elegans{\textquoteright} bacterial inhabitants jokingly strike up a conversation with everyone there. Sheep with light and heavy infections gained more weight after receiving M. oleifera treatment and had lower fecal egg counts than control groups; sheep with light infection had a 100\% reduction in egg count. The serum concentrations of IL-2, IL-17, and IgG all significantly decreased after M. oleifera treatment. There were significantly higher levels of IL-10 in sheep with both mild and severe infections. C{\textquoteright}s feces contained noticeably fewer bacteria after taking moringa extract. The two novyi groups had varying degrees of infection severity. Fabricio (F. (as well as OleiferaMdot). C. noteworthy and novyi. M. oleifera aqueous extracts showed a concentration-dependent ovicidal effect on F. gigantica non-embryonated.

}, keywords = {Anthelmintic, Antimicrobial, Cytokines, Moringa oleifera, Public health.}, doi = {10.5530/pj.2023.15.44}, author = {Maslichah Mafruchati and Wan Irjani Wan Ismail} } @article {2092, title = {RETRACTED: Human Sperm for Basic Embryo Research And 3D Treatment of Patient-Representative Ovarian Cancer Cells}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {August 2023}, pages = {626-632}, type = {Research Article}, chapter = {626}, abstract = {

The article has been retracted based on the authors{\textquoteright} request.

}, keywords = {3D treatment, Basic embryo research, Human sperm, Ovarian cancer cells, Public health.}, author = {Maslichah Mafruchati and Wan Irjani Wan Ismail} } @article {1711, title = {Liver-Histological Improvement after Capsaicin Administration in Mice with Aflatoxin B1 oxication}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {December 2021}, pages = {1577-1581}, type = {Original Article}, chapter = {1577}, abstract = {

Context: Public health issues are considered to provide safety for public consumption. The distribution of mycotoxins in food is still a concern to be solved. Capsaicin is a property in chili that inhibits the biotransformation of mycotoxins by modifying the activity of liver enzymes in phase I. Objectives: A total of 20 mice were divided into 4 treatment groups, namely (T0) 0.5 ml of polyethylene glycol, (T1) 0.5 ml of capsaicin + 0.5 ml of polyethylene glycol, (T2) 0.1 ml of aflatoxin B1 + 0.5 ml of polyethylene glycol, (T3) 0.1 ml of aflatoxin B1 + 0.5 ml of capsaicin, respectively. Methods: Liver histology was performed with hematoxylin-eosin staining and then evaluated descriptively. Result: The T3 group showed significant improvement in sublobular vein, interlobular vein, centralis vein, interlobular duct. Meanwhile, based on scores of hepatocyte form, focal necrosis, hypertrophy, fibrosis, cholestasis, and steatosis were evaluated for improvement in the T3 group. Conclusion: Capsaicin was revealed to improve the liver histology in mice with aflatoxin B1 toxication.

}, keywords = {Aflatoxin B1, Capsaicin, Liver, Public health.}, doi = {10.5530/pj.2021.13.202}, author = {Mohammad Sukmanadi and Mustofa Helmi Effendi and Faisal Fikri and Muhammad Thohawi Elziyad Purnama} }