@article {1811,
	title = {Role of Alkaloid on Platelet Aggregation and Serotonin in Migraine},
	journal = {Pharmacognosy Journal},
	volume = {14},
	year = {2022},
	month = {June 2022},
	pages = {629-632},
	type = {Research Article},
	chapter = {629},
	abstract = {<p class="rtejustify">Migraine is a sterile neurogenic inflammation of the trigeminal nerve which releases vasoactive neuropeptides and activates platelets to release vasoactive substances such as serotonin (5-HT). Platelet hyperaggregation occurs in the pathogenesis of migraine caused by one of the stimulatory factors 5-HT. Platelet aggregation is increased and 5-HT levels are elevated in the blood and brain in the early stages of migraine. Alkaloid β-carbolin alkaloids can increase monoamines in brain regions through inhibition of monoamine oxidase (MAO) and inhibition of 5-HT reuptake. Alkaloids in the ethanolic extract of SCE function as analgesics and anti-inflammatory which can reduce pain and improve blood circulation. <em>Sargassum cristaefolium</em> extract (SCE) was measured for its bioactive substance content. The extract was administered to an animal model of intraperitoneal nitroglycerin-induced migraine and examined for platelet levels, platelet aggregation and 5-HT. The results of statistical tests showed an increase in platelets (p\&lt;0.05), an increase in platelet aggregation (p\&lt;0.05) and a decrease in 5-HT (p\&lt;0.05). The relationship between alkaloids and platelets; platelets and platelet aggregation; platelet aggregation and 5-HT and 5-HT levels and migraine incidence (p\&lt;0.05). The alkaloids found in SCE can lower platelet count, decrease platelet aggregation and increase 5-HT levels in migraines.</p>
},
	keywords = {Alkaloid, Migraine, Platelet, Platelet aggregation, Serotonin.},
	doi = {10.5530/pj.2022.14.81},
	author = {Olivia Mahardani Adam and Widjiati Widjiati}
}
