@article {1953, title = {The Effect of Channa striata Extract on Serum Albumin and High Sensitive C-Reactive Protein in End-Stage Renal Disease Patients: A Randomized Controlled Trial}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {March 2023}, pages = {1-5}, type = {Original Article }, chapter = {1}, abstract = {

Background: Albumin is a marker of nutritioinal inflammation and mortality. Chronic inflammation, as indicated by the concentration of a proinflammatory cytokine, high sensitivity C-reactive protein (hs-CRP) was reported to be high in end-stage renal disease (ESRD) patients. Channa striata (CS) contains high protein that can increase albumin levels and has anti-inflammatory effects. This study was conducted to determine the effect of CS extract on serum albumin and hs-CRP on ESRD patients. Methods: This study is a randomized, double blind, placebo-controlled study in patients with ESRD on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD). Subjects were randomized to either a CS or a placebo group and were given a three times daily dosage of 500 mg of CS extract or 500 mg maltodextrin, respectively for 21 days. Serum albumin and hs-CRP were measured at the baseline, and at the end of the study. Result: Forty subjects were randomized into the study with 20 in the Channa striata group and 20 in the placebo group, with HD and CAPD patient evenly distributed among the group. Significant increase in serum albumin levels (p\<0,001) and significant decrease of hs-CRP (p\<0,001) were observed in the treatment group compared to control group at the end of the study. At the end of the study, there was no significant difference between serum albumin, hs-CRP, and their gradient between HD and CAPD patients in the intervention group. Conclusion: CS extract results in higher serum albumin and lower hs-CRP levels compared to placebo in our population.

}, keywords = {Albumin, Channa striata, End-stage renal disease, hs-CRP, Supplementation.}, doi = {10.5530/pj.2023.15.1}, author = {Wachid Putranto and Septina Hestiningrum and Nur Ismi Mustika Febriani and Kusmardi Kusmardi and Ratih Tri Kusuma Dewi and Santy Ayu Puspita Perdhana and Nurhasan Agung Prabowo and Yeremia Suryo Pratama} } @article {1870, title = {Artificial Sweeteners Perturbed Liver Enzymes in Rat Model}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {October 2022}, pages = {553-557}, type = {Research Article}, chapter = {553}, abstract = {

In the recent time there has been an increased demand of low-fat or low calorie diet universally. In the mean while the availability of low calorie products has also increased like sugar free drinks, beverages, biscuits, jams and jellies. On contrary to this, some studies suggest that the prolong use of non-nutritive sweeteners alters the homeostasis of glucose and insulin. It results in fluctuation of glucose level in blood and increase in bodyweight. This study intends to evaluate the effect of non-nutritive sweeteners on the liver function test and record the alteration in the levels of ALP, AST and ALT. Seventy rats were divided into seven equal groups, controlled group received distilled water and the rest six were given NNS Sucrose, Stevia, Sucralose, Saccharine Aspartame and Acesulfame-k, respectively. On the evaluation of Alanine aminotransferase ALT, saccharine and aspartame markedly increased the level of ALT from 40U/L to 80 U/L. Both of these NNS have shown the most raised level of Alanine aminotransferase. This represents the stress on the liver associated with the use of NNS and suggests the use to be controlled in humans.

}, keywords = {Albumin, Artificial Sweeteners, Bilirubin, Liver Enzyme}, doi = {10.5530/pj.2022.14.135}, author = {Muthear N Dawood and Shaymaa AH. Jassim and Maab Azmi Fadel and Imad A. Thanoon} } @article {1866, title = {Isolation and Characterization of Snakehead Fish Meal Extract with Fresh, Boiled, and Steamed Treatments and Its Potential for Health Drinks and Immunomodulators}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {October 2022}, pages = {532-536}, type = {Original Article}, chapter = {532}, abstract = {

Albumin is one of the proteins that currently have an important role for the organism{\textquoteright}s body. This study aims to determine the characteristics of albumin with several treatments which will later be applied to cendol drinks. The treatments for extraction and albumin flour were fresh, boiled, and steamed, which were tested for extract yield, amino acids, and molecular identification using SDS-Page. The results showed that the steam treatment of the extract produced the highest yield of 0.42g/dL. The highest amino acid was in albumin flour with boiled treatment, namely each essential amino acid, namely leucine and non-essential amino acid, namely leucine. Identification of albumin molecular weight showed that albumin was found only in fresh and flour conditions when fresh. Other results indicate the possibility of processing factors affecting the presence of albumin which is easily soluble in water. albumin isolation from snakehead fish can potentially be developed into immunomodulatory health products

}, keywords = {Albumin, Extract, Food product, Immunomodulator, Sds page.}, doi = {10.5530/pj.2022.14.131}, author = {Dewita and Desmelati and Santhy W. Sidauruk and Taufik Hidayat} }