@article {2446, title = {Preeclampsia: A Cardiorenal Syndrome in Obstetric Intensive Care Unit}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {December 2024}, pages = {1439-1441}, type = {Case Report}, chapter = {1439}, abstract = {

Introduction: Cardiorenal syndrome (CRS) encompasses a spectrum of disorders involving heart and kidneys. Preeclampsia and cardiovascular disease are most likely occur via oxidative stress induced endothelial dysfunction. Case presentation: A 34-years-old woman was referred with difficulty of breathing. She had a history of preeclampsia and refractory acute kidney injury (AKI). The patient was diagnosed with severe preeclampsia, partial HELLP syndrome, acute lung edema, cardiomyopathy, CRS, anemia, hyperkalemia, hypoalbuminemia, and AKI. Discussion: CRS and preeclampsia share similar risk factors and mechanisms including pre-existing renal or cardiac disease, diabetes, chronic hypertension, hypertriglyceridemia, obesity, metabolic syndrome, or other systemic disease. She had a history of preeclampsia and refractory AKI. Cardiac dysfunction reduce arterial blood supply and impairs venous return. Renal failure leads to the retention of water and an excessive volume demand. Conclusion: Cardiovascular disorders leading to CRS and preeclampsia remain the leading cause of morbidity in pregnancy.

}, keywords = {Cardiorenal syndrome, Hypertension, Preeclampsia}, doi = {10.5530/pj.2024.16.232}, author = {Mohamad Evandiar Izwardy and Mariza Fitriati} } @article {2000, title = {Antihypertensive Choices during Pregnancy in Limited Setting}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {April 2023}, pages = {315-318}, type = {Original Article }, chapter = {315}, abstract = {

Background: Antihypertensive agents used during pregnancy may vary from institution to institution and depend on resource availability. Objective: This study aimed to determine the profile of antihypertensive drugs used in pregnancy in low-middle-income countries and the impact of these drugs on maternal and fetal outcomes. Materials and Methods: This is a retrospective study on hypertensive pregnant patients admitted to the emergency unit at a tertiary referral Hospital in Indonesia. The type of hypertension during pregnancy, antihypertensive drugs, side effect, and maternal and perinatal outcomes was extracted from medical hospital records. Results: A total of 762 hypertensive pregnant women were recruited; 61 were diagnosed with preeclampsia, 491 were preeclampsia with severe features and 174 were chronic hypertension superimposed preeclampsia, and 81.54\% of them received antihypertension therapy. The most commonly prescribed antihypertensive drugs were combination therapy of nifedipine and methyldopa (96.7\%), followed by monotherapy of methyldopa (2.3\%), nicardipine (1.1\%), and nifedipine (0.2\%). Most of the patients successfully attained a Systolic blood pressure\<160mmHg. Tachycardia was reported in 47 (7.9\%) pregnant women who received antihypertensive medication; none reported hypotension and arrhythmia. Conclusion: Nifedipine and methyldopa are choices for an antihypertensive agent in limited resources, either monotherapy or combined. Nifedipine{\textquoteright}s immediate release can be used with a low risk of hypotension.

}, keywords = {Antihypertensive agent, Chronic hypertension, Hypertension during pregnancy, Preeclampsia, Side effect.}, doi = {10.5530/pj.2023.15.46}, author = {Ernawati and Aditiawarman and Salsabila Nabilah Rifdah and Agus Sulistyono} }