@article {1038, title = {Effect of Fibroblast Growth Factor Combination with Ethanol Extract of Morinda citrifolia L. on Blood Glucose Levels}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {November 2019}, pages = {1558-1562}, type = {Research Article}, chapter = {1558}, abstract = {

A research has been conducted on the effect of giving Fibroblast Growth Factor (FGF) with Morinda citrifolia L. ethanol extract. This study aims to determine whether the administration of a combination of FGF with ethanol extract of noni fruit can reduce blood glucose levels in diabetes mice induced by alloxan. FGF requires amino acids in regenerating pancreatic β cells, where the amino acids expected from noni fruit can provide a signal response in regenerating pancreatic β cells. In addition, the active substances contained in noni fruit namely xeronine and flavonoid alkaloids can function to reduce blood glucose levels. Test animals were divided into 6 groups, each group consisted of 10 male white mice. Group 1 is a normal control group is a group without any given. Group 2 was a negative control group given 150 mg/kg alloxan. Group 3, 4, and 5 are the treatment groups that are given alloxan and the combination of noni fruit ethanol extract with 3 variations of dose (125; 350; and 1000) mg / KgBW plus FGF dose of 800 mg / kgBW, group 6 is the comparison which is only given FGF alone at a dose of 800 mg / kgBW. The study was conducted for 21 days, observed every 7th, 14th, 21st day using the Easy Touch{\textregistered}\ GCU digital device. The results of this study showed that administration of noni fruit ethanol extract with FGF was able to reduce blood glucose levels by significance (p \<0.05) and based on the percentage calculation of blood glucose levels as much as 44.9\% at a dose of 1000 mg / kgBW on the day observations 21st.

}, keywords = {Diabetes mellitus, FGF, Morinda citrifolia}, doi = {10.5530/pj.2019.11.238}, author = {Dharma S and Rahmawati Y and Nessa and Dillasamolla S} } @article {426, title = {In vitro \& ex vivo Acetylcholinesterase Inhibitory Activity of Morinda citrifolia Linn (Noni) Fruit Extract}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {900-905}, type = {Original Article}, chapter = {900}, abstract = {

Background: Psychological problem is a key medical issue for numerous neuropsychiatric and neurodegenerative diseases, for example, schizophrenia, Alzheimer\’s, dementia, seizure and Parkinsonism. Morinda citrifolia (Noni) has been utilized for a considerable length of time to cure or counteract assortment of diseases by conventional therapeutic professionals in Hawaii and Polynesia. Objective: The present study is focused to identify the neuroprotective activity of Morinda citrifolia fruit extract (MCFE) on in vitro and ex vivo animal model by inhibition of acetylcholinesterase (AChE), an enzyme target used for the treatment of Alzheimer\’s disease. Methods: Acetylcholinesterase inhibition assay was performed by in vitro \& ex vivo methods as described by Ellman et al. In vitro antioxidant assay of the extract was performed by DPPH free radical scavenging activity \& nitric oxide scavenging activity. Statistical analysis used: Statistical analysis was carried out using non linear regression analysis for plotting the line of best fit for the observed values using Graph- Pad Prism software. Results: By performing in vitro antioxidant assay the IC50 value of the standard quercetin was found to be 46.22 \μg/ml as compared to the MCFE which has an IC50 value of 43.14 \μg/ml for DPPH free radical scavenging activity. Similarly the IC50 value of the standard ascorbic acid was found to be 81.85 \μg/ml as compared to the MCFE which has an IC50 value of 148.0 \μg/ml for nitric oxide scavenging activity. Acetylcholinesterase inhibition assay was performed by in vitro method and the IC50 value of MCFE and neostigmine was found to be 31.84 \μg/ml \& 19.71 \μg/ml respectively. Conclusions: The present study investigated the neuroprotective activity of MCFE and it was identified by both in vitro and ex vivo techniques that the phytoconstituents has the ability to improve the learning and memory function by inhibiting the acetylcholinesterase.

}, keywords = {Acetylcholinesterase, ex vivo., in vitro, Morinda citrifolia, Neuroprotective activity, Noni}, doi = {10.5530/pj.2017.6.141}, url = {http://fulltxt.org/article/194}, author = {Srikanth Jeyabalan and Kavimani Subramanian and Uma Maheswara Reddy Cheekala and Chitra Krishnan} } @article {173, title = {Health Benefits of Morinda citrifolia (Noni): A Review}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {June/2016}, pages = {321-334}, type = {Review Article}, chapter = {321}, abstract = {

Background: Morinda citrifolia (Noni) has been used widely as a complementary and alternative therapy in many countries owing to its potent antioxidant activity and proven health benefits. Traditionally, it finds used as a therapeutic remedy to various diseases as an antibacterial, antitumor, anthelminthic, analgesic, anti-inflammatory, immunostimulant. Also it has proved beneficial in conditions like gastritis, skin diseases, respiratory infections, menstrual and urinary tract disorders, fever, diabetes and venereal diseases. Objective: This review emphasizes on the phytochemical and mineral profile of the different parts of Noni plant. In addition, this review corroborates the pharmacological basis for the various health benefits, traditional and medicinal applications of Noni. Materials and Methods: All the available information of Noni were collected from electronic databases such as Academic Journals, Ethnobotany, Ethnopharmacology, Springer, PubMed, Google Scholar, Science Direct and other primary and secondary sources. Results: According to our search results pertaining to scientific literature, Morinda citrifolia is used for more than 40 types of ailments worldwide. Crude extract of various parts of plant and fruit juice are reported to contain amino acids, anthraquinones, fatty acids, flavonoids, iridoids, lignans, polysaccharides, sterols, sugars, terpenoids etc. which are therapeutically useful for a broad range of pathological conditions. Fourteen human clinical trials have validated the remarkable health benefits of Noni. Conclusion: Literatures prove that Noni is pharmacologically active and is used in different forms of cancer, viz. colon, esophageal, breast, colorectal cancers; cardiovascular diseases, diabetes, arthritis, hypertension. These properties are substantiated by the preclinical or/and clinical investigations.

}, keywords = {Anticancer., Antioxidant, Morinda citrifolia, Neutraceutical, Phyto-constituents}, doi = {10.5530/pj.2016.4.4}, author = {Mohammad Ali and Mruthunjaya Kenganora and Santhepete Nanjundaiah Manjula} }