@article {1263, title = {Southeast Asian Medicinal Plants with Angiotensin Converting Enzyme (ACE) Inhibition Properties}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {September 2020}, pages = {1429-1439}, type = {Research Article}, chapter = {1429}, abstract = {

Introduction: This article aims to provide a summary of medicinal plants in the Southeast Asian countries that have an angiotensin-converting enzyme (ACE) inhibitory activity that is therapeutically useful for treating hypertension. Methods: This review paper is a result of extensive searches via electronic database platforms, including Pubmed, Google Scholar, Scopus, and Science Direct with the keyword search terms: ACE enzyme, Southeast Asia countries, plants, and extracts. Results: Thirty-four articles on ACE inhibition activity of 76 Southeast Asian medicinal plants were found and further reviewed. Several plants from Malaysia (Chassalia curviflora, Citrus hystrix, Murraya koenigii, Senna garrettiana), Indonesia (Gnetum Gnemon, Momordica charantia, Nasturtium officinale, Peperomia pellucida, Pereskia saccharose), and Thailand (Mammea siamensis) were found to exhibit strong ACE inhibitory activity in vitro. Bioactive compounds such as 3{\textquoteright},4{\textquoteright}, dihydroxy-3-5 dimethoxy flavone-7-O- β-rhamnose and quercetin-3-O-glucoside showed the highest potency in exhibiting the ACE inhibition activity in this review. Conclusions: This review suggests for an in-depth investigation on the potent crude extracts for the potential development of complementary herbal medicines as well as on the potent ACE inhibitor compounds for further development as new ACE inhibitor candidates for hypertension therapy.

}, keywords = {ACE, Angiotensin-converting enzyme, Antihypertensive, Medicinal plants, Southeast Asia}, doi = {10.5530/pj.2020.12.197}, author = {T A Faiz T Anuar and Azlini Ismail} } @article {259, title = {Effect of Gamma Irradiation on Angiotensin Converting Enzyme Inhibition, Antioxidant Activity, Total Phenolic Compound and Total Flavonoid of Peperomia pellucida Herbs Extract}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {February 2017}, pages = {244-248}, type = {Original Article}, chapter = {244}, abstract = {

Introduction: Peperomia pellucida L. Kunth has been reported to have some biological activities such as antihypertensive and antioxidants. Herbal materials susceptible to contamination during processing and storage which can shortens their shelf life. Gamma-irradiation has been used as a method for preservation. Methods: This research aimed to analyze the effect of gamma-irradiation on inhibition activity of angiotensin converting enzyme (ACE), antioxidant activity, total phenol content, total flavonoid, and thin layer chromatography profiles of P. pellucida L. Herbs extract. The extract was irradiated with 60Co gamma rays at 2.5; 5; 7.5; dan 10 kGy. Results: Irradiation up to 10 kGy did not change ACE inhibitory activity and TLC profile. No significant differences were noted in the inhibition activity of ACE and the type of chromatogram profiles between non-irradiated extract and irradiated extracts up to a dose of 10 kGy while total flavonoids showed a significant decrease. In addition, total phenolic content and antioxidant activity showed a significant increase of extracts were irradiated up to 5 kGy and decrease at dose 7,5 kGy and 10 kGy. Gamma-irradiation up to 10 kGy didn\’t affect the activity of ACEinhibitor in-vitro while significant difference (P \<0.05) of antioxidant activity, total flavonoids and phenolic content of the extract P. Pellucida. Conclusion: In conclusion, gamma - irradiation can be used as a preservation method for ethanol extract P. Pellucida L. Kunth herbs.

}, keywords = {ACE, Antioxidant, Extract, Gamma-irradiation, Peperomia pellucida, Total flavonoids, total phenolic}, doi = {10.5530/pj.2017.2.41}, url = {http://phcogj.com/fulltext/308}, author = {Anies Monica Adhitia and Alisa Nur Octaviani and Rissyelly and Katrin Basah and Abdul Mun{\textquoteright}im} }