01981nas a2200205 4500008004100000245011700041210006900158260001700227300001400244490000700258520134200265653002401607653001401631653002201645653001501667100001701682700001901699700002101718856003601739 2019 eng d00aChemical Constituents and Anti-Ulcer Activity of Ethylacetate Extract of the Leaves of Sanchezia nobilis Hook.F.0 aChemical Constituents and AntiUlcer Activity of Ethylacetate Ext cOctober 2019 a1172-11800 v113 a

Study have two objectives. First objective is about the identification of the five components. The second objective is about the antiulcer activity of the ethylacetate extract. Five compounds (1–5) were isolated from the leaves of Sanchezia nobilis Hook.F. collected in Nam Dinh province by chromatographic methods. These compounds were identified as: Quercetin (1), Scopoletin (2), Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (3), Quercetin-3-O-α-L-rhamnosyl-(1→6)-β-D-glucopyranosyl-(1→3)-β-D-glucopyranoside (4),3’-Omethyl- 3,4-methylenedioxy ellagic acid (5).Their structures were elucidated by spectroscopic methods, including mass spectrometry (MS) and nuclear magnetic resonance (NMR). Compounds 3, 4, 5 were isolated from the leaves of Sanchezia nobilis Hook.F. for the first time. Evaluation the effect of gastric and duodenal anti-ulcer on cyteamine induced gastric ulcer models indicates at this ethylacetate extract has the effect to improve the extent of ulcer lesions treatment (54,17 %); obviously reduced the average of number pocket of ulcers (1,85 ± 0,80) and ulcer index (5,61 ± 2,69), however, it does not change the area of the ulcer.

10aAnti-ulcer activity10aQuercetin10aSanchezia nobilis10aScopoletin1 aDuc, Loi, Vu1 aThi, Xuan, Bui1 aMinh, Ngoc, Tran uhttps://phcogj.com/article/1003