02420nas a2200253 4500008004100000245010000041210006900141260001700210300001400227490000700241520162700248653001501875653002101890653002901911653002501940653001701965653002501982100002502007700002802032700002602060700002102086700002302107856003602130 2019 eng d00aEffects of Eurycoma Longifolia Jack (Tongkat Ali) Alcoholic Root Extract Against Oral Pathogens0 aEffects of Eurycoma Longifolia Jack Tongkat Ali Alcoholic Root E cOctober 2019 a1299-13020 v113 a

Introduction: Eurycoma longifolia jack (E.L) is a herbal medicinal plant of South-East Asian origin, popularly recognized as ‘Tongkat Ali.’ The plant roots have been scientifically proven to have many biological effects including antibacterial activity however, no previous research to date has studied the effect on oral pathogens including cariogenic bacteria. This study was done to determine the antibacterial and antifungal activities of E.L. root extract against three common oral pathogens. Material and Methods: The microorganisms used were Candida albicans, Streptococcus mutans and Lactobacillus casei. E.L root was extracted using soxhlet method. Disc diffusion assay was conducted using extract concentration of 200 mg/ml. Nystatin and Ampicillin were used as positive control for fungal and bacterial tests respectively. Minimum Inhibitory Concentration (MIC) was done to determine the lowest inhibitory concentration of the extract on the microorganisms. Results: E.L extract inhibited the growth of Candida albicans and Streptococcus mutans at a concentration of 200 mg/ ml with a zone of inhibition of 16.0 ± 3.0 mm and 7.0 ± 1.0 mm respectively. There was no antimicrobial effect of the extract on Lactobacillus casei. The MIC of E.L extract against both Candida albicans and Streptococcus mutans was 25 mg/ml. Conclusions: The results from this study revealed the potential use of Eurycoma longifolia jack as an antimicrobial agent which can be used to produce new oral care products.

10aAntifungal10aCandida albicans10aEurycoma longifolia Jack10aLactobacillus casei.10aRoot extract10aStreptococcus mutans1 aAlloha, Irani, Binti1 aAziz, Nurul, ‘Ain Liy1 aFaisal, Ghasak, Ghazi1 aAbllah, Zurainie1 aArzmi, Mohd, Hafiz uhttps://phcogj.com/article/1013