02073nas a2200205 4500008004100000245009000041210006900131260001700200300001400217490000700231520146900238653002201707653001601729653002601745100001701771700000501788700001701793700002101810856003601831 2019 eng d00aAnti-inflammatory Effect of Phyllanthus niruri L. from Indonesia (Pre-clinical Study)0 aAntiinflammatory Effect of Phyllanthus niruri L from Indonesia P cOctober 2019 a1347-13500 v113 a

Indonesian people often use Phyllanthus niruri L. (P. niruri L.) to treat pain. Pain is the one of symptoms of inflammation. Some people take traditional medicine to treat this pain, because some analgesic drugs have several adverse effects. The aim of this research is to explore the anti-inflammatory effect of ethyl asetat fraction of ethanolic extract of P. niruri L. (EAPN) from Indonesia in rats induced by carrageenan. A total of 25 rats were divided into 5 groups. Group 1 (diclofenac sodium 50 mg/kgbb), group 2 (aqueous extract), groups 3,4and 5 were ethyl asetat fraction at dosage of 250; 500 and 1000 mg/kgbw respectively. Group 1 was treated by diclofenac sodium at dose of 50 mg/kgbw, group II was treated by aqueous 2mL/rats, groups III, IV and V were treated by EAPN at dosage of 250; 500 and 1000mg/kgbw respectively. Thirty minutes later, all rats were injected by carrageenan 0,1 mL 1% w/v sub cutaneous into back rat’s left paw. Paw volumes were measured by Plethysmometer on minutes 0, 60, 90, 150, 210, 330. Area under the curve (AUC) were calculated from these results (AUC 0-30; AUC 0-90; 0-150; AUC 0-210 and AUC 0-330). The AUC of EAPN at dosage of 250; 500 and 1000mg/ kgbw smaller than negative control significantly (P<0.05). EAPN contains alkaloids, flavonoids, terpenoids, saponins and triterpens. EAPN has anti-inflammatory effect in rats induced by carrageenan.

10aAnti-inflammatory10aCarrageenan10aPhyllanthus niruri L.1 aSutrisna, Em1 a1 aWahyuni, Sri1 aS, Tanti, Azizah uhttps://phcogj.com/article/1016