02124nas a2200241 4500008004100000245013700041210006900178260001200247300001000259490000600269520137900275653002501654653001601679653001001695653002801705653001601733100001701749700001601766700002101782700002101803700002301824856003501847 2016 eng d00aThe Anticancer Potential of Pavonia odorata extract on Human Breast (MD-MB-231), Prostate (PC-3) and Lung (Calu-6) Cancer cell lines0 aAnticancer Potential of Pavonia odorata extract on Human Breast  c09/2015 a28-300 v83 a

Introduction: A huge reservoir of bioactive compounds exists in many species of plants, only a small percentage of which have been examined and continued to be an important source of anticancer agents. Worldwide effects are ongoing to identify new anticancer compounds from plants. With the current decline in the number of new molecular entities from the pharmaceutical industry, novel anticancer agents are being sought from traditional medicines. Objective: In the present study we investigated the efficacy of methanol extracts of Pavonia odorata, for its clonogenic inhibition on Human Breast cancer (MD-MB-231), Prostate cancer (PC-3) and Lung cancer (Calu-6) cell lines. Materials and Methods: The cytotoxic effect was evaluated by MTT assay. Results: The methanol extract of P. odorata showed significant cytotoxicity against MD-MB-231 and Calu-6, when compared to PC-3cells. Conclusion: The methanol extracts of P. odorata, showed effective cytotoxic activities in a dose dependent manner. Future work will be interesting to know the chemical composition and also better understanding the mechanism of action will help in developing it as drug for therapeutic application.

10aAlternative medicine10aAnti-cancer10aDrugs10aIndian Medicinal plants10aInhibition.1 aV, Girish, H1 aB, Vinod, A1 aL, Dhananjaya, B1 aD, Satish, Kumar1 aDuraisamy, Senthil uhttps://phcogj.com/article/102