02550nas a2200217 4500008004100000245009400041210006900135260001700204300001400221490000700235520189600242653001102138653001402149653002502163100002802188700002202216700001902238700001902257700002002276856003602296 2019 eng d00aEffect of Tender Coconut Water to Prevent Anemia on Wistar Rats Induced by Lead (Plumbum)0 aEffect of Tender Coconut Water to Prevent Anemia on Wistar Rats  cOctober 2019 a1325-13300 v113 a

Background: Tender coconut water (TCW) is a nutritious healthy drink, some content as L-arginin, iron, vitamin C, vitamin B6, folic acid and fatty acid have roles during the process of blood formation (hematopoesis). Lead (Pb) is one of heavy metal which can trigger the formation of Reactive Oxygen Species (ROS), causing oxidative stress and hematopoetic stem cell disorders which cause the decrease of hematocrit, hemoglobin and erythrocyte levels as the sign of anemia. Aim and Objectives: This research to investigate the effect of tender coconut water to prevent anemia on lead induced rats. Material and Methods: Experimental research by post test only control group design, using 18 white wistar strain male rats randomly divided into 3 groups. Group K1 served as control, Group K2 was fed lead (10 mg/day/rat), Group K3 was given tender coconut water (8 mL/200gr BW rats/ day) orally for four weeks. Rats’ blood from ophtalmicus venous was analyzed using Hematology Analyzer to measure the hemoglobin, hematocrit, and erythrocyte levels. Data were analyzed using Anova test and Kruskal Wallis. Results:That decreased levels of hematocrit, hemoglobin and erythrocyte were show in group K2 compared with group K1. Increased levels of hematocrit, hemoglobin and erythrocyte were observed significantly in both groups K3 than K2. Conclusion: Results of the present study have administration of tender coconut water (8 mL/200gr BW rats/ day for 4 weeks) could increased of hematocrit, hemoglobin and erythrocyte levels (p <0.05). The administration of tender coconut water has proven to prevent the anemia indicated by the increase of hematocrit, hemoglobin and erythrocyte levels on wistar strain male rats induced by lead.

10aAnemia10aLead (Pb)10aTender coconut water1 aZulaikhah, Siti, Thomas1 aWahyuwibowo, Joko1 aD, Aziz, Rakha1 aP, Dede, Rizky1 aN, Ahmad, Fauzi uhttps://phcogj.com/article/1020