02003nas a2200193 4500008004100000245011200041210006900153260001800222300001400240490000700254520139800261653002001659653001201679653001501691653002501706653001401731100002801745856003601773 2019 eng d00aAnthelmintic Activity of Millettia pachycarpa Root Bark Extract on an Intestinal Roundworm, Ascaridia galli0 aAnthelmintic Activity of Millettia pachycarpa Root Bark Extract  cNovember 2019 a1428-14330 v113 a

Background: Millettia pachycarpa Benth. is member of the family Fabaceae and is a wellknown traditional medicinal plant used for different health conditions. Its roots and seeds are rich in bioactive compounds such as chalcones, isoflavones and rotenoids, which are attributed to the anticancer, antiparasitic and insecticidal properties of the plant. In Mizo traditional medicine, the root bark is also used for parasitic infections. Objective: The study was designed to understand the anthelmintic efficacy and effects of M. pachycarpa on an intestinal roundworm, Ascaridia galli. Materials and Methods: The methanolic extract of the root bark was prepared and survival test was performed against A. galli. The structural effects were studied using scanning electron microscopy and histological preparations. Results: The roundworm showed extensive structural changes and damages. The cuticle showed extensive shrinkage and cracks. Lacerations and scars distorted the fine transverse rings. The mouthparts collapsed with shrunken lips and degenerated denticles. Internal tissues such as musculature and reproductive organs were also impaired. Conclusion: The findings indicate that the plant extract is effective against parasitic roundworms.

10aAscaridia galli10aCuticle10amicroscopy10aMillettia pachycarpa10aRoundworm1 aLalchhandama, Kholhring uhttps://phcogj.com/article/1044