01923nas a2200241 4500008004100000245009900041210006900140260001800209300001400227490000700241520120500248653001201453653003201465653001601497653000901513653001001522100002801532700001901560700001801579700002701597700002101624856003601645 2019 eng d00aEthanol Extract of Gardenia augusta (L.) Merr. Flowers Produces Sleep Improvement in Rat Model0 aEthanol Extract of Gardenia augusta L Merr Flowers Produces Slee cNovember 2019 a1449-14540 v113 a

Introduction: Sleep disorder may have detrimental consequences on health and one of the treatments is the use of hypnotics. Unfortunately, hypnotics treatment may also be accompanied by side effects and lead to dependence. The present study aimed to investigate the sleep improving effects of ethanol extract of Gardenia augusta (L.) Merr. flowers in rat model. Methods: Rats were assigned into group receiving the extract (at 0.9 or 1.8 g/kg), the reference drug crocetin (at 0.9 mg/kg) or vehicle, once a day orally for 15 days. Results: Tested on day 1 and 14 of treatment, the rats receiving 1.8 g/kg of the extract showed improvements in sleep latency, sleep duration, sleep efficiency, wake episodes, and sleep cycle, which were significantly different from crocetin. Furthermore, tested on day 2 and 15 of treatment, the rats treated with 1.8 g/kg extract demonstrated superior sedative rating scale compared to crocetin. Conclusions: Results of the present study indicates the potential of Gardenia augusta (L.) Merr. flower extract to be used as an adjunct treatment for sleep disorder.

10aFlowers10aGardenia augusta (L.) Merr.10aImprovement10aRats10aSleep1 aAnggadiredja, Kusnandar1 aAdnyana, Ketut1 aSafitri, Dewi1 aRahmawati, Siti, Farah1 aHendrayana, Tomi uhttps://phcogj.com/article/1049