02091nas a2200229 4500008004100000245012400041210006900165260001800234300001400252490000700266520135700273653001701630653002401647653001501671653001701686653001401703100003101717700002101748700002901769700002701798856003601825 2019 eng d00aAntimalarial Activity of Microalgae Extracts Based on Inhibition of PfMQO, a Mitochondrial Plasmodium falciparum Enzyme0 aAntimalarial Activity of Microalgae Extracts Based on Inhibition cNovember 2019 a1477-14820 v113 a

Malaria is an important global disease that threatened human life. The resistance Plasmodium sp. to the available medicines encourages the search for new antimalarial substances based on new mechanisms on the inhibition of PfMQO (the mitochondrial Plasmodium falciparum enzyme). Objective: The purposes of this study was to screen antimalarial substances from microalgae based on the inhibition of PfMQO. Materials and Methods: Five microalgae were extracted by maceration using chloroform pa and ethanol pa. These ten crude extracts obtained were tested for the inhibitory activity against the PfMQO enzyme. Results: The highest inhibitory activity against PfMQO enzyme was chloroform extract of S. costatum with 91.050% of inhibition and 0.043 μg/mL of IC50. The ethanol extract of S. platensis showed 91.999% and 5.25 μg/mL of inhibition and IC50, respectively. These results indicated that the two extracts provide high antimalarial activity exceeded a theoretical standard of antimalarial bioactive compounds. Conclusion: Chloroform extract of S. costatum and ethanol extract of S. platensis are promising sources of antimalarial compounds based on the inhibition of PfMQO.

10aAntimalarial10aInhibitory activity10aMicroalgae10aP falciparum10aScreening1 aSetyowati, Endang, Ariyani1 aIsnansetyo, Alim1 aDjohan, Tjut, Sugandawat1 aNurcahyo, Raden, Wisnu uhttps://phcogj.com/article/1053