02423nas a2200193 4500008004100000245009700041210006900138260001900207300001200226490000700238520180200245653002602047653003302073653002302106653002302129100001902152700002202171856003602193 2020 eng d00aEvaluation of Traditional Herb Extract Salvia officinalis in Treatment of Alzheimers Disease0 aEvaluation of Traditional Herb Extract Salvia officinalis in Tre cFebruary 2020 a131-1430 v123 a

Aim and Objective: Alzheimer’s disease is progressive neurodegenerative disorder which affects older individuals. It is the most common cause of dementia and it is associated with the presence of senile plaques which are deposition of beta- amyloidal protein in the hippocampus area of the brain. Medicinal plants have played vital role in world health. In spite of the great advances observed in modern medicine in recent decades, plants still make an important contribution to health care. The present study is done to evaluate Salvia officinalis, for in vivo study on Alzheimer’s disease induced mice. Materials and Methodology: Memory Enhancing Activity, Conditioned avoidance test, Y-maze spontaneous alternation test, Elevated Plus Maze, Morris Water Maze, Measurement of Locomotor Activity were done to assess memory and cognitive functioning. The isolated brain homogenate is estimated for reduced glutathione content, Acetyl cholinesterase Activity, Superoxide dismutase assay (SOD), Lipid peroxidation assay (TBARS), Glutathione peroxidase assay (GSH-Px) and Histopathology examination of brain was performed and analyzed. Results and Discussion: The elevated level of enzymes and decreased level of tissue antioxidant markers were observed in treatment comparative to piracetam treatment group. While 300 mg/kg extract significantly reduced the elevated levels of the enzymes and also significantly increased the tissue antioxidant levels, while decreased the glutathione levels when compared with the control. Conclusion: The histopathological study confirmed the recovery. The herbal extract (150 and 300 mg/kg) has shown effectiveness against Alzheimer’s disease.

10aAlzheimer’s disease10aHistopathological assessment10aLocomotor activity10aSalvia officinalis1 aDatta, Sanjana1 aPatil, Shailendra uhttps://phcogj.com/article/1073