02922nas a2200229 4500008004100000245014400041210006900185260001900254300001000273490000700283520218600290653001402476653003602490653001902526653002502545653000902570653002102579100001602600700002202616700001802638856003602656 2020 eng d00aActivity of Kincung Flowers (Etlingera Elatior (Jack) R.M.Sm.) on Total Leukocytes and Percentage of Leukocytes in Allergic Male White Mice0 aActivity of Kincung Flowers Etlingera Elatior Jack RMSm on Total cFebruary 2020 a44-510 v123 a

Introduction: Kincung Flower (Etlingera elatior (Jack) R.M.Sm.) is a native herbal plant in Southeast Asia that traditionally used to many diseases, especially in Indonesia. Aim: This study was conducted to determine the activity of kincung (Etlingera elatior (Jack) R.M.Sm.) on the total number of leukocytes and differential leukocyte cells in allergic mice. Material and Methods: The semi-solid extract of Kincung flower (Etlingera elatior (Jack) R.M.Sm.) was made by the maceration method using 70% ethanol solvent. The animals used were 20 male white mice that have allergies of skin that treated with 20% albumen antigens given on the first day 0.2 mL/20 g intraperitoneally, then on the seventh day are given antigens with the same dose subcutaneously. Allergic mice indicated by redness at the injection site. It divided into four groups: the negative control group and three dose groups (100; 300; and 1000 mg/kg). On the seventh day after administration of the extract, observed the value of total leukocytes and differential leukocyte cells in mice. Results: The results after administration of extracts in 3 dose groups (100; 300; and 1000 mg / kg) and the negative control group showed sequentially the total number of leukocytes was: 3.95; 4.73; 6.01; and 3.6 x103/μL and the percentage of leukocytes consisting of lymphocytes: 67.6%; 62.0%; 56.8% and 70.0%, neutrophils: 22.4%; 29.2%; 36.8% and 20.0%, eosinophils: 6.4%; 5.8%, 4.2% and 6.6%, monocytes: 3.6%; 3.0%, 2.2% and 3.4%, and basophils: 1.8%; 1.4; 0.8% and 2.0%. It concluded that kincung flowers could increase total leukocytes significantly (p<0.05), decrease lymphocytes, eosinophils, basophils significantly (p<0.05), increase neutrophils significantly (p<0.05), and reduce monocytes insignificantly (p>0.05). Conclusion: Kincung flowers (Etlingera Elatior (Jack) R.M.Sm.) can be used as an immunomodulator and decreasing the percentage of basophil cells, and eosinophils can used as an anti-allergic drug.

10aAllergies10aEtlingera elatior (Jack) R.M.Sm10aKincung Flower10aLeukocyte Percentage10aMice10aTotal Leukocytes1 aAldi, Yufri1 aHusni, Elidahanum1 aYesika, Relin uhttps://phcogj.com/article/1077