02611nas a2200229 4500008004100000245014500041210006900186260001900255300001200274490000700286520186800293653000802161653001202169653001902181653002302200653003102223100002402254700001902278700002002297700002802317856003602345 2020 eng d00aTender Coconut Water Inhibits the Process of Lipid Peroxidation, Reduce Glucose Levels and Increase Plasma Insulin in Pregnant Diabetic Rats0 aTender Coconut Water Inhibits the Process of Lipid Peroxidation  cFebruary 2020 a162-1670 v123 a

Background: Diabetes during pregnancy or Gestational Diabetes Mellitus (GDM) causes oxidative stress and have bad effect for mother and baby, risk of abortion, still birth, premature and preeclampsia. GDM can be prevented by monitoring the glucose level and providing rich antioxidants meals. TCW is a nutritious healthy drink rich in antioxidants, diet rich in antioxidants promotes better health, Inhibits lipid peroxidation and enhances the total antioxidant status. Aim and Objectives: This research to investigate the effect of tender coconut water can prevent lipid peroxidation, reduce glucose levels and increase insulin plasma level on pregnant diabetic rats. Material and Methods: Experimental study by post test only control group design, population of pregnant wistar strain rats. Twenty four samples used in this study were randomly divided into 4 groups, K1 (pregnant rats), K2 (pregnant rats+diabetic), K3 (pregnant rats+diabetic+ glibenklamid 0.23 mg/kg BW ) and K4 (pregnant rats+diabetic+TCW 8mL/200grBW). Diabetes Mellitus were induced using Streptozotocin (STZ) 65mg/kgBW and Nicotinamid 230 mg/kgBW. Data on insulin plasma, glucose and MDA levels were analyzed using One Way Anova with significant level 0.05. Result: The results showed that the average insulin plasma levels in group 2 decreased compared to group 1 , in group 3 and 4 it increased compared to group 2. Average glucose and MDA levels in group 2 increased compared to group 1 , in group 3 and 4 it decreased compared to group 2. The results of the analysis has the p values 0.000 (p<0.05). Conclusion: TCW can inhibit the process of lipid peroxidation, reduce glucose levels, increase insulin plasma levels and in pregnant diabetic rats.

10aGDM10aGlucose10aInsulin plasma10aLipid peroxidation10aTender coconut water (TCW)1 aNova, Friday, Super1 aChasani, Shofa1 aHussanna, Atina1 aZulaikhah, Siti, Thomas uhttps://phcogj.com/article/1078