01728nas a2200217   4500008004100000245007000041210006900111260001500180300001200195490000700207520110100214653002201315653003301337653001401370653001401384653001601398100002301414700001801437700001901455856003601474       2020                        eng d00aEffects of Pearl Grass Extract Capsules on Osteoarthritis Subject0 aEffects of Pearl Grass Extract Capsules on Osteoarthritis Subjec  cMarch 2020  a303-3100 v123 a<p class="rtejustify">Pearl grass extract, a standardized bioactive polar extract of the herbs of Hedyotis corymbosa, is preclinically proven to have an activity to osteoarthritis and rheumatoid arthritis properties in an animal model. The current clinical study has evaluated the efficacy and safety of Pearl grass extract of osteoarthritis subjects. This research was a pilot study of osteoarthritis subjects using Parallel double-blind study design. Subjects have normal renal and liver function, above 50 years of age, and has a sign and symptoms of osteoarthritis included in the study. In the treatment, Pearl grass capsules were given as one capsule once daily for eight weeks, throughout the study, the weekly assessment to evaluate the adverse event. Thirty subjects of mean age 55.90 ± 3.7 years were evaluable. Pearl grass extract capsules did not change renal and liver function in 56 days treatment. Pearl grass capsule markedly reduced the consumption of analgesic drug compared with placebo groups. Pearl grass capsules also decreased pain scale better compare with placebo.</p>
10aClinical efficacy10aPearl grass extract capsules10aQuercetin10aVAS scale10aWOMAC scale1 aWijaya, Nita, Sari1 aBasah, Katrin1 aBahtiar, Anton  uhttps://phcogj.com/article/1100