01741nas a2200229 4500008004100000245008900041210006900130260001500199300001200214490000700226520104900233653001701282653003001299653002001329653001901349100002401368700001701392700002401409700001701433700002501450856003601475 2020 eng d00aAntidiabetic Constituents from Helminthostachys zeylanica (L) Hook (Ophioglossaceae)0 aAntidiabetic Constituents from Helminthostachys zeylanica L Hook cMarch 2020 a223-2260 v123 a
Background: The roots of tunjuk langit (Helminthostacshys zeylanica) have been used traditionally in some villages in Indonesia, particularly in Riau Province. Objective: In this study we reported two flavonoids and their antidiabetic activity. Material and methods: Isolation of the metabolites was based on polarity fractionation method. Purification processes were conducted by vacuum liquid chromatography (VLC). Chemical structures were elucidated based on spectroscopy characteristics, including FTIR and 1D/2D NMR. Results: The isolated compounds were identified as ugonin J and K. The antidiabetic activity was measured by α-glucosidase inhibitor assay. The antidiabetic activity of ugonin J was found at IC50 273,13±0,402 ppm and Ugonin K was found at IC50 138,21±0,263 ppm (moderately active). Conclusion: Therefore this plant can be used traditionally as antidiabetic medicine.
10aAntidiabetic10aHelminthostacys zeylanica10aOphioglossaceae10aα-glucosidase1 aRidhasya, Fania, El1 aRahim, Novia1 aAlmurdani, Muhammad1 aHendra, Rudi1 aTeruna, Hilwan, Yuda uhttps://phcogj.com/article/1102