02478nas a2200241   4500008004100000245007100041210006900112260001500181300001200196490000700208520181500215653001802030653001402048653001702062100001902079700001602098700001602114700001802130700001602148700001802164700001802182856003602200       2020                        eng d00aStudy of Quality Medicinal Plants Bark Walnuts and Extract from it0 aStudy of Quality Medicinal Plants Bark Walnuts and Extract from   cMarch 2020  a282-2860 v123 a<p class="rtejustify"><strong>Objective: </strong>The bark of walnut is currently poorly understood and is not represented in the Russian State Pharmacopeia. The purpose was to study the quality indicators medicinal plants walnut crust and extracts therefrom were studied: moisture content, total ash, ash insoluble in 10% hydrochloric acid feedstock walnut crust; content of tannins and juglone in walnut crust; GC-mass spectrometric study of the composition petroleum extract from the bark of a walnut. <strong>Materials and Methods: </strong>Microscopy was prepared by the pharmacopoeial method. The chemical composition of the petroleum extract was investigated by chromatomass spectrometry. <strong>Results:</strong> The content of glycosides amount in terms of gidroyuglone glucoside and absolutely dry RL was 5.30 ± 0.15. Humidity was 9,41% ± 0,21. total ash content was 10,18% ± 0,1. The ash content insoluble in 10% hydrochloric acid was 4.8 ± 0.16. Gas chromatography-mass spectrometry method in petroleum extraction from the bark of walnut were identified following compounds: oktadetsilgeksanoat (28%) of 4-isopropenyl- 1-methyl-2-cyclohexenol-1 (38%), cineole (1,6%), thujone (0.7%), camphor (16.6%), 2 - benzamidoantrahinone (0.45%), 4,5 - dihydroxy - 3,4 - dihydro - 1 (2H) - naftalenon (6.4%) ethyl ester of palmitic acid (8.25%) Toxic effects petroleum extract was TD50 = 2,5. Chronic absent. All mice in the experimental group had diarrhea. It was established that the extraction has petroleum anthelmintic properties at askaridioze. <strong>Conclusions: </strong>The analysis of petroleum extraction from walnut partitions was carried out, the content of basic biologically active substances was revealed. The main anatomical and diagnostic signs of walnut bark walls were studied.</p>
10aJuglans regia10aTotal ash10aToxic effect1 aAV, Strelyaeva1 aDI, Lezhava1 aAN, Luferov1 aRM, Kuznetsov1 aNV, Bobkova1 aYuB, Lazareva1 aEN, Kostikova  uhttps://phcogj.com/article/1104