02357nas a2200349 4500008004100000245008900041210006900130260001500199300001200214490000700226520140600233653001501639653001301654653003801667653001701705100001401722700002001736700001701756700001701773700000501790700001701795700001801812700001801830700001601848700002001864700001501884700001701899700002201916700001601938700001701954856003601971 2020 eng d00aPharmacopoeial Analysis of Inulin-Containing Medicinal Plant Raw Materials and Drugs0 aPharmacopoeial Analysis of InulinContaining Medicinal Plant Raw cMarch 2020 a415-4210 v123 a
Background: Today, there are some unresolved issues and discussions concerning inulin quantitative determination in medicinal plant raw materials (MPRM). MPRM containing polyfructans or fructosans (inulin and others) are rather complex multicomponent matrixes with many interacting compounds. The article discusses the prospects for further standardization of inulin-containing pharmacopoeial MPRM that include, in addition to polysaccharides (inulin), other biologically active compounds with pharmacological activity. Materials and Methods: Different types of search tools such as Google scholar, Google, scientific literature, normative documentation of Russian Federation (State Pharmacopoeia of Russian Federation IV edition and others) electronic databases such as e-Library, Scopus, Web of Science, Pubmed had been searched and data obtained. Results: The pharmacopoeial spectrophotometric procedures of inulin determination in the Russian Federation are approved in a version that does not fully satisfy modern standardization criteria. Regulatory changes required in the near future. Conclusion: Undoubtedly, to determine inulin quantitatively, it is necessary to modify the existing spectrophotometric procedures and introduce an additional alternative, more specific HPLC-RID (or similar) ones.
10aFructosans10aHPLC-RID10aInulin quantitative determination10aPolyfructans1 aDO, Bokov1 aDI, Karabeshkin1 aIA, Samylina1 aOG, Potanina1 a1 aAD, Malinkin1 aEV, Sergunova1 aTYu, Kovaleva1 aNV, Bobkova1 aAM, Antsyshkina1 aAA, Bondar1 aAA, Evgrafov1 aEK, Galiakhmetova1 aDV, Moiseev1 aVV, Bessonov uhttps://phcogj.com/article/1125