02929nas a2200289 4500008004100000245012900041210006900170260001300239300001200252490000700264520205800271653001602329653001402345653002302359653002102382653001402403653002202417653001602439100001602455700001402471700002702485700003102512700002202543700001702565700002102582856003602603 2020 eng d00aNeuro-protective Effect of Ayurveda Formulation, Saraswatharishtam, on Scopolamine Induced Memory Impairment in Animal Model0 aNeuroprotective Effect of Ayurveda Formulation Saraswatharishtam cMay 2020 a465-4720 v123 a

Introduction: In the management of neurodegenerative and neuropsychiatric diseases, memory loss remains very challenging. Saraswatharishtam (SWRT) is an ayurvedic formulation prescribed for several neurological ailments like acute anxiety, partial memory loss, slurred speech, neuro-degenerative diseases like Parkinson’s, Alzheimer’s etc. Methods: Present study explores the possibilities of curative effects of SWRT on Scopolamine induced memory impairment and to compare the effects of commonly used drug Piracetam. Adult Wistar Swiss albino mice were used for this experiment and divided into five different groups for the treatments of the drugs in various combinations. The first group was vehicle treated control while the second group was treated with scopolamine to induce memory impairment. The third groups of animals were treated with Scopolamine where the mice were pretreated with standard neuro-protective drug Piracetam, while the fourth and fifth groups of animals were treated with scopolamine and the animals were pretreated with SWRT at the doses of 200 and 400 mg/kg respectively to compare with the effect of Piracetam. Scopolamine was administered on day eight, only for 45 minutes in all the cases (Group I- Group V). Several neurobehavioral parameters were examined to confirm the neuro-protective effects of SWRT. Results: Saraswatharishtam significantly reversed the memory loss in mice model as revealed from elevated plus maze, radial maze and rectangular maze experiments justifying its neuroprotective potential as observed in usually used synthetic Piracetam. SWRT was found to be nontoxic and very promising antioxidant recorded from acute and chronic toxicological studies. Conclusions: It is suggested that SWRT, could be used as safe and easily available Ayurveda medicine to treat neurological dysfunctions without any side effects. Further translational research is needed to explore its neuro-protective potential.

10aAntioxidant10aAyurvedic10aElevated Plus Maze10aNeuro-protection10aPiracetam10aSaraswatharishtam10aScopolamine1 aPrabhu, Jai1 aPrabhu, K1 aChaudhuri, Anathbandhu1 aRao, Mudiganti, Ram Krishn1 aSelvi, V, S Kalai1 aBalaji, T, K1 aDinakar, Shruthi uhttps://phcogj.com/article/1134