02245nas a2200229 4500008004100000245012700041210006900168260001300237300001300250490000700263520151200270653002001782653002801802653002301830653001701853653002301870653002801893100001801921700002201939700001801961856003601979 2020 eng d00aMemory Enhancing Efficacy of an Ayurvedic Polyherbal Formulation on Scopolamine-Induced Memory Deficit Experimental Models0 aMemory Enhancing Efficacy of an Ayurvedic Polyherbal Formulation cMay 2020 a589-597 0 v123 a

The present study was performed to determine the efficacy of an ayurvedic polyherbal formulation (PHF) in the learning and memory process of animal models. The prepared PHF was a suspension of three plant extracts i.e. Alpinia galanga (AG), Glycyrrhiza glabra (GG) and Convolvulus pluricaulis (CP) along with other excipients. Learning and memory assessment of PHF was performed using different behavioral models in scopolamine-induced memory impairment animals. Biochemical estimation was performed to determine the enzymatic level of MDA, GSH and AChE level in rats. Results indicated that the time of social investigation trial 2 (SIT2) was reduced significantly compared to SIT1 due to the treatment of PHF. In the water maze test, plant extracts significantly decreased the latency time in the 4th and 5th sessions comparing to session 1. Administration of AG, CP, GG, and PHF caused amelioration of scopolamine-induced memory impairment in the MWM test. The extracts and PHF were also effective in reducing latency time in the pole climbing test. Biochemical parameters exhibited a reduction in MDA and AChE levels with an increase in GSH level after treatment with extracts and PHF. It can be concluded from the study that PHF is an effective formulation for learning and memory processes against scopolamine-induced memory impairment. Further, the isolation of active constituents is desired from different plant extracts.

10aAlpinia galanga10aConvolvulus pluricaulis10aGlycyrrhiza glabra10aLatency time10aPole climbing test10aSocial recognition test1 aShukla, Deepa1 aSrivastava, Sajal1 aJawaid, Talha uhttps://phcogj.com/article/1149