02401nas a2200241 4500008004100000245009500041210006900136260001400205300001200219490000700231520167400238653001601912653001501928653002101943653003901964100001902003700001702022700002602039700001802065700002202083700001802105856003602123 2020 eng d00aThe Nephroprotective And Antioxidant Activity of Sterculia rubiginosa Zoll. Ex Miq. Leaves0 aNephroprotective And Antioxidant Activity of Sterculia rubiginos cJune 2020 a843-8490 v123 a

Background: Sterculia has an antioxidant activity. The Sterculia genus has phenols and flavonoids content, and this chemical content may be have an nephroprotective activity. Objective: The study was to investigate the in vitro study of antioxidant activity with DPPH and FRAP study and nephroprotective activity of Sterculia rubiginosa Zoll. Ex Miq. Leaves extract. Materials and Methods: The leaves was extracted using ethanol. This extract was determined for antioxidant activity by in vitro study with DPPH and FRAP methods, determined the content of total phenols, total flavonoids, and also identification of chemical content. Nephrotoxicity study done by induced gentamycin. The groups divided 6 group, consist: negative control, positive control, normal control, and the extract with dose 50 mg/kg, 100 mg/kg, and 200 mg/ kg. The parameter for nephroprotective activity was tubular necrosis, the presence of tubules casts and glomerular damage, creatinine serum, and urea. Results: The ethanol extract has IC50 162.34 μg/ml for DPPH scavenging activity and 18.65 ± 3.53 FeEAC (Mol/g) for FRAP. The secondary metabolite presence flavonoids, tannins, terpenes, alkaloids, and glycosides. The total phenols 462.36 ± 9.23 mg GAE/gr, total flavonoids content 59.44 ± 0.11 mg QE/gr extract. All the dose have an nephroprotective activity, but the best dose was 50 mg/kg. Conclusion: The ethanol extract of Sterculia rubiginosa showed antioxidant activity and nephroprotective activity.

10aAntioxidant10aGentamicin10aNephroprotective10aSterculia rubiginosa Zoll Ex. Miq.1 aPrastiwi, Rini1 aDewanti, Ema1 aFadliani, Inka, Nurul1 aAqilla, Nessa1 aSalsabila, Salwaa1 aLadeska, Vera uhttps://phcogj.com/article/1185